Background: CXC chemokine ligand-12 (CXCL12) is released during brain injury. The objective of this study was to investigate relationship between serum CXCL12 concentration, mortality and trauma severity in patients with traumatic brain injury (TBI).
Methods: We determined serum CXCL12 concentration of 132 controls and 132 patients with severe TBI. Trauma severity was assessed using Glasgow Coma Scale (GCS) score. The end-point of the study was 30-day mortality.
Results: Serum CXCL12 concentration were significantly higher in the patients than in the controls (13.3±6.8 vs. 1.5±0.5 ng/ml, P<0.001). There was a negative correlation between CXCL12 concentration and GCS scores (r=-0.588, P<0.001). The optimal cutoff value of CXCL12 as a mortality indicator was estimated to be 15.4 ng/ml, which yielded a sensitivity of 71.0% and a specificity of 72.2%, with the area under curve at 0.808 [95% confidence (CI), 0.730-0.871]. Serum CXCL12 concentration>19.5 ng/ml were associated independently with 30-day mortality (odds ratio, 6.951; 95% CI, 2.027-18.477; P<0.001) and 30-day overall survival (hazard ratio, 4.398; 95% CI, 2.088-15.286; P<0.001).
Conclusions: Increased serum CXCL12 concentration is associated highly with trauma severity and mortality following TBI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cca.2015.12.033 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inhibition of Abdominal Aortic Aneurysm Progression Through the CXCL12/CXCR4 Axis via MiR206-3p Sponge.
J Cell Mol Med
January 2025
Department of Vascular Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Notably, the C-X-C Motif Chemokine Ligand 12/C-X-C Chemokine Receptor Type 4 (CXCL12/CXCR4) signalling pathway's activation is markedly increased in a mouse model of abdominal aortic aneurysms (AAA). Nonetheless, the precise contribution of this pathway to AAA development remains to be elucidated. The AAA mouse model was induced by local incubation with elastase and oral administration of β-aminopropionitrile.
View Article and Find Full Text PDFA Targeted Proteomics Approach Reveals a Serum Protein Signature as a Diagnostic Biomarker for Colorectal Cancer.
J Inflamm Res
December 2024
Central Laboratory, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511400, People's Republic of China.
Background: Circulating proteins secreted by tumors are an important source of cancer biomarkers. This study aims to investigate the changes in the content of tumor immune-related circulating proteins in peripheral blood from patients with colorectal cancer (CRC).
Methods: Olink's proximity extension assay was used to detect the levels of 92 tumor immune-related circulating proteins in peripheral blood from CRC patients.
Increased serum EGF but not SDF-1 levels are associated with the pathophysiology and development of generalized anxiety disorder.
Sci Rep
November 2024
School of Pharmacy, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, Dhaka, 1212, Bangladesh.
Article Synopsis
- Generalized anxiety disorder (GAD) is a common mental illness characterized by uncontrollable worries, influenced by various factors like genetics, environment, and daily stress.
- A study involving 50 GAD patients and 38 healthy controls found that GAD patients had significantly higher serum levels of epidermal growth factor (EGF), which correlated positively with the severity of their symptoms.
- While EGF levels showed potential as a diagnostic biomarker for GAD, serum levels of stromal cell-derived factor-1 (SDF-1) did not significantly differ between GAD patients and healthy controls.
Identification and validation of diagnostic markers related to immunogenic cell death and infiltration of immune cells in diabetic nephropathy.
Int Immunopharmacol
December 2024
Department of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University (Hangzhou Hospital of Traditional Chinese Medicine), Hangzhou 310007, Zhejiang, China. Electronic address:
Introduction: Immunogenic cell death (ICD) is a unique cell death triggered by chemotherapy. However, studies elucidating the potential therapeutic role of ICD and the underlying mechanism in diabetic nephropathy (DN) are limited.
Methods: WGCNA was conducted on the human kidney biopsy data linked to DN, analyzing gene sets associated with ICD.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!