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Usefulness of mid-regional proadrenomedullin levels in the resuscitation phase of severely burned patients and its utility in early sepsis detection.
Burns
August 2024
Intensive Medicine Department, Hospital Universitario La Paz, Madrid, Spain.
Introduction: Mid-regional proadrenomedullin (MR-proADM) reflects the adrenomedullin level, which has vasodilatory activity, decreases endothelial permeability, and downregulates proinflammatory cytokines. Sepsis diagnosis in these patients is difficult, and MR-proADM is a widely studied sepsis biomarker. This study evaluates MR-proADM levels during the resuscitation phase, considering the potential influence of haemodynamic changes and its usefulness for the early sepsis detection in burn patients.
View Article and Find Full Text PDFBiomarkers as Prognostic Predictors and Therapeutic Guide in Critically Ill Patients: Clinical Evidence.
J Pers Med
February 2023
Department of Anesthesiology and Surgical Intensive Care, University Hospital of La Princesa, 28006 Madrid, Spain.
A biomarker is a molecule that can be measured in a biological sample in an objective, systematic, and precise way, whose levels indicate whether a process is normal or pathological. Knowing the most important biomarkers and their characteristics is the key to precision medicine in intensive and perioperative care. Biomarkers can be used to diagnose, in assessment of disease severity, to stratify risk, to predict and guide clinical decisions, and to guide treatments and response to them.
View Article and Find Full Text PDFUsefulness of monocyte distribution width (MDW) as a sepsis biomarker.
Rev Esp Quimioter
April 2022
Juan González del Castillo, Servicio de Urgencias. Hospital Clínico San Carlos. Calle Profesor Martín-Lagos s/n, 28040 Madrid. Spain.
Sepsis is one of the main causes of mortality in the emergency department (ED), due to the fact that signs and symptoms are common to other acute diseases, and this can result in delayed detection. This diagnostic complexity has a huge impact on an entity in which early recognition determined treatment, as wells as enhance the patient's prognosis. Therefore, it is crucial to improve early identification.
View Article and Find Full Text PDFPlasma Levels of Mid-Regional Proadrenomedullin Accurately Identify H1N1pdm09 Influenza Virus Patients with Risk of Intensive Care Admission and Mortality in the Emergency Department.
J Pers Med
January 2022
CHRU Nîmes, 30900 Nimes, France.
Early identification of severe viral pneumonia in influenza virus A (H1N1pdm09) patients is extremely important for prompt admission to the ICU. The objective is to evaluate the usefulness of MR-proadrenomedullin (MR-proADM) compared to C reactive protein (CRP), procalcitonin (PCT), and ferritin in the prognosis of influenza A pneumonia. This prospective, observational, multicenter study included one hundred thirteen patients with confirmed influenza virus A (H1N1pdm09) admitted to an Emergency Department and ICUs of six hospitals in Spain.
View Article and Find Full Text PDFMR-Proadrenomedullin as biomarker of renal damage in urinary tract infection in children.
BMC Pediatr
June 2021
Servicio de Pediatría, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Background: Midregional-proadrenomedullin (MR-proADM) is a useful prognostic peptide in severe infectious pathologies in the adult population. However, there are no studies that analyze its utility in febrile urinary tract infection (fUTI) in children. An accurate biomarker would provide an early detection of patients with kidney damage, avoiding other invasive tests like renal scintigraphy scans.
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