We report on the discovery of strong intensity variations in the high rotational lines of abundant molecular species towards the archetypical circumstellar envelope of IRC+10216. The observations have been carried out with the HIFI instrument on board and with the IRAM 30-m telescope. They cover several observing periods spreading over 3 years. The line intensity variations for molecules produced in the external layers of the envelope most probably result from time variations in the infrared pumping rates. We analyze the main implications this discovery has on the interpretation of molecular line emission in the envelopes of Mira-type stars. Radiative transfer calculations have to take into account both the time variability of infrared pumping and the possible variation of the dust and gas temperatures with stellar phase in order to reproduce the observation of molecular lines at different epochs. The effect of gas temperature variations with stellar phase could be particularly important for lines produced in the innermost regions of the envelope. Each layer of the circumstellar envelope sees the stellar light radiation with a different lag time (phase). Our results show that this effect must be included in the models. The sub-mm and FIR lines of AGB stars cannot anymore be considered as safe intensity calibrators.
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http://dx.doi.org/10.1088/2041-8205/796/1/L21 | DOI Listing |
Background: Although invasiveness is one of the major determinants of the poor glioblastoma (GBM) outcome, the mechanisms of GBM invasion are only partially understood. Among the intrinsic and environmental processes promoting cell-to-cell interaction processes, eventually driving GBM invasion, we focused on the pro-invasive role played by Extracellular Vesicles (EVs), a heterogeneous group of cell-released membranous structures containing various bioactive cargoes, which can be transferred from donor to recipient cells.
Methods: EVs isolated from patient-derived GBM cell lines and surgical aspirates were assessed for their pro-migratory competence by spheroid migration assays, calcium imaging, and PYK-2/FAK phosphorylation.
Front Cell Dev Biol
January 2025
Mechanobiology Laboratory, Nagoya University Graduate School of Medicine, Nagoya, Japan.
The high interstitial ATP concentration in the cancer microenvironment is a major source of adenosine, which acts as a strong immune suppressor. However, the source of ATP release has not been elucidated. We measured ATP release during hypotonic stress using a real-time ATP luminescence imaging system in breast cell lines and in primary cultured mammary cells.
View Article and Find Full Text PDFJ Hepatocell Carcinoma
January 2025
Departments of Pharmacology, School of Pharmacy, Qingdao University Medical College, Shandong, People's Republic of China.
Objective: Artesunate can inhibit the proliferation of various tumor cells and has practical value in developing anti-tumor drugs. However, its biological activity against hepatocellular carcinoma is weak. The efficacy of its anti-tumor effect needs to be improved.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Physics and Engineering, Albany State University, GA 31707. USA. Electronic address:
This work represents a comprehensive study of the ground vibrational state of C-13 substituted methanol using very high-resolution far-infrared (FIR) and infrared (IR) Synchrotron Radiation spectra recorded with a very high signal-to-noise (S/N) ratio in the entire region from 40to5000cm, at the Canadian Light sources. High resolution combined with a high S/N ratio allowed the recording to be done with an unprecedented resolution of about 0.0017cm.
View Article and Find Full Text PDFRadiat Oncol
January 2025
Department of Radiotherapy and Radiooncology, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Dusseldorf, Germany.
Background: Medulloblastoma is the most common malignant pediatric brain tumor, typically treated with normofractionated craniospinal irradiation (CSI) with an additional boost over about 6 weeks in children older than 3 years. This study investigates the sensitivity of pediatric medulloblastoma cell lines to different radiation fractionation schedules. While extensively studied in adult tumors, these ratios remain unknown in pediatric cases due to the rarity of the disease.
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