AI Article Synopsis
- Tyrosine kinase inhibitors (TKIs) targeting EGFR are effective treatments for advanced non-small cell lung cancer (NSCLC), and this study looked at the role of EGFR gene amplification in these patients.
- The research involved 290 patients, using specific testing methods (MLPA and PCR) to detect EGFR gene amplification and mutations.
- Although EGFR amplification was found in 9% of patients, it was more common in those with EGFR mutations; however, it did not correlate with improved survival and is not a reliable predictive biomarker for TKI treatment.
Article Abstract
Background: Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) represent novel, effective tools in the management of advanced-stage non-small cell lung cancer (NSCLC). We aimed to evaluate the incidence and predictive role of EGFR gene amplification in patients with advanced-stage NSCLC treated with EGFR-TKIs.
Patients And Methods: The study included 290 patients with advanced-stage (IIIB or IV) NSCLC. Multiplex ligation-dependent probe amplification (MLPA) and polymerase chain reaction (PCR) were used for detection of EGFR gene amplification and EGFR mutations, respectively.
Results: EGFR amplification was detected in 26 (9.0%) patients. EGFR amplification was found more frequently in patients harboring the EGFR mutation (p<0.001). No significant corelation between EGFR gene amplification and survival was observed.
Conclusion: EGFR gene amplification is associated with EGFR gene mutation. EGFR gene amplification is not a feasible predictive biomarker for treatment with EGFR-TKIs in patients with advanced-stage NSCLC.
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