AI Article Synopsis
- ALDH1 is identified as a potential cancer stem cell marker in various cancers, but its role in tumor cells and their microenvironment remains unclear.
- The study analyzed ALDH1 protein in 157 esophageal squamous cell carcinoma (ESCC) samples and found that high ALDH1 expression in tumor cells is linked to poor differentiation and shorter overall survival rates.
- Contrary to the findings in tumor cells, ALDH1 expression in the surrounding stromal cells did not show any significant relationship with clinical features, suggesting a need for further research to understand the underlying mechanisms.
Article Abstract
Background: Aldehyde dehydrogenase-1 (ALDH1) has been shown to be a potential cancer stem cell marker in different types of cancer. However, the role of its expression in tumor cells and the microenvironment in different types of cancer is still controversial.
Materials And Methods: ALDH1 protein was immunohistochemically investigated and analyzed in 157 samples of surgically dissected esophageal squamous cell carcinoma (ESCC) tissues.
Results: ALDH1 protein expression in ESCC tumor cells was significantly associated with poor differentiation (p<0.05) and strongly positive ALDH1 expression in tumor cells was related with shorter overall survival (p<0.05), while the expression of ALDH1 in ESCC stromal cells had no significant relationship with clinicopathological features (p>0.05).
Conclusion: High expression of cancer stem cell marker ALDH1 in ESCC cells may thus portend a poor prognosis. However, its expression in the tumor microenvironment did not appear to have a role in ESCC behavior. More studies are warranted to find out the mechanisms to explain this.
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