AI Article Synopsis
- Surgical site infections (SSI) from Staphylococcus aureus are serious and can lead to high mortality and morbidity, prompting the need for effective prevention strategies.
- A study analyzed data from 249 patients with S. aureus SSI compared to 54,988 uninfected individuals, uncovering various risk factors tied to certain surgical procedures and the overall severity of the patient's condition.
- Findings showed that longer hospital stays, specific surgeries like colectomy, and other factors increased the risk for S. aureus SSI, while minimally invasive surgeries offered some protection, suggesting targeted prevention efforts could help high-risk patients.
Article Abstract
Background: Surgical site infections (SSI) due to Staphylococcus aureus are associated with substantial mortality rates and morbidity. Hence, various strategies are being investigated to prevent them. We explore time trends and risk factors associated with S. aureus SSI to identify high risk patients who might benefit the most from these strategies.
Methods: This is a retrospective cross-sectional study on a prospectively maintained database. We identified organism specific risk factors for S. aureus SSI as a whole, methicillin-sensitive S. aureus (MSSA), and methicillin-resistant S. aureus (MRSA). We also identified procedure-specific risk factors for S. aureus SSI for colectomy, hip, and knee arthroplasty, herniorrhaphy, and cholecystectomy.
Results: We compared 249 patients with S. aureus SSI with 54,988 uninfected control patients. The rate of S. aureus SSI was steady throughout the study period with MSSA being more common than MRSA. Independent risk factors for S. aureus SSI from multivariable analysis were length of hospitalization prior to surgery [odds ratio (OR) 1.01; 95% confidence interval (CI), 1.00-1.02)], colectomy (OR 2.81; 95% CI, 1.94-4.07), hip or knee arthroplasty (OR 1.52; 95% CI, 1.04-2.21), extended duration of surgery (OR 1.61; 95% CI, 1.10-2.37), NNIS score of two or more (OR 2.04; 95% CI, 1.24-3.36), and re-interventions for non-infectious reasons (OR 1.82; 95% CI, 1.16-2.86). Minimally invasive (OR 0.21; 95% CI, 0.13-0.34) and emergency operations (OR 0.61; 95% CI, 0.41-0.92) were protective against S. aureus SSI.
Conclusions: Future S.aureus SSI prevention measures should focus on patients with risk profiles identified from this and other similar studies.
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| http://dx.doi.org/10.1089/sur.2015.055 | DOI Listing |
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