The first total synthesis of (±)-gelsenicine is reported. The synthetic route is highly efficient (13 steps), featuring (1) a pivotal metal-catalyzed isomerization/rearrangement process that forges the central core of the molecule and (2) two facile C-N bond-forming steps that establish the flanking heterocycles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732274 | PMC |
| http://dx.doi.org/10.1021/jacs.5b12263 | DOI Listing |
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