AI Article Synopsis
- Nutraceuticals are natural compounds that provide health benefits and are in high demand, leading to a multi-billion dollar market.
- Supply issues and extraction challenges from natural sources limit their large-scale use.
- Metabolic engineering using microbes, like E. coli and S. cerevisiae, offers an eco-friendly solution for producing these valuable compounds more efficiently.
Article Abstract
Nutraceuticals are important natural bioactive compounds that confer health-promoting and medical benefits to humans. Globally growing demands for value-added nutraceuticals for prevention and treatment of human diseases have rendered nutraceuticals a multi-billion dollar market. However, supply limitations and extraction difficulties from natural sources such as plants, animals or fungi, restrict the large-scale use of nutraceuticals. Metabolic engineering via microbial production platforms has been advanced as an eco-friendly alternative approach for production of value-added nutraceuticals from simple carbon sources. Microbial platforms like the most widely used Escherichia coli and Saccharomyces cerevisiae have been engineered as versatile cell factories for production of diverse and complex value-added chemicals such as phytochemicals, prebiotics, polysaccaharides and poly amino acids. This review highlights the recent progresses in biological production of value-added nutraceuticals via metabolic engineering approaches.
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| http://dx.doi.org/10.1016/j.copbio.2015.11.003 | DOI Listing |
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