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| http://dx.doi.org/10.1186/s13054-015-1174-4 | DOI Listing |
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Department of Cardiovascular Medicine, Department of Medicine, Lahey Hospital and Medical Center, Burlington, MA, USA.
Introduction: Immunotherapy has transformed cancer treatment, particularly with immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy. Despite their efficacy, these therapies can induce cardiotoxicity, presenting significant clinical challenges. Immune checkpoint inhibitors can cause myocarditis; pericarditis; arrhythmias; and myocardial infarction through immune-mediated inflammation.
View Article and Find Full Text PDFSmall for Size Syndrome in Living Donor Liver Transplantation- Prevention and Management.
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Institute of Liver Disease & Transplantation, Gleneagles Health City, Chennai, India.
Small-for-size syndrome is a clinical syndrome of early allograft dysfunction usually following living donor liver transplantation due to a mismatch between recipient metabolic and functional requirements and the graft's functional capacity. While graft size relative to the recipient size is the most commonly used parameter to predict risk, small-for-size syndrome is multifactorial and its development depends on a number of inter-dependant factors only some of which are modifiable. Intra-operative monitoring of portal haemodynamics and portal flow modulation is widely recommended though there is wide variation in clinical practice.
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Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, ON, Canada.
Article Synopsis
- Semaglutide, a drug that slows down stomach emptying, may pose risks for patients undergoing surgery due to potential increased residual gastric content and aspiration during anesthesia, especially if taken within 10 days before the operation.
- In a study with 220 patients, those who had taken semaglutide showed a significantly higher incidence (40%) of increased gastric content compared to only 3% in the control group.
- The findings suggest that using semaglutide pre-operatively raises the risk of residual gastric content, although there were no reported cases of aspiration during the surgeries.
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