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Three dimensional patient-specific collagen architecture modulates cartilage responses in the knee joint during gait. | LitMetric

AI Article Synopsis

  • Collagen fibril orientations in knee joint cartilage can influence stress levels, but this has not been thoroughly examined through 3-D models until now.
  • A new evaluation method was developed to assess how patient-specific collagen structure affects cartilage mechanical responses during walking by using 3-D finite element models based on real MRI data.
  • Results showed that using a patient-specific model led to significantly lower fibril strains and stresses in certain regions of cartilage compared to a generalized literature model, highlighting the importance of personalized collagen architecture in understanding knee joint mechanics.

Article Abstract

Site-specific variation of collagen fibril orientations can affect cartilage stresses in knee joints. However, this has not been confirmed by 3-D analyses. Therefore, we present a novel method for evaluation of the effect of patient-specific collagen architecture on time-dependent mechanical responses of knee joint cartilage during gait. 3-D finite element (FE) models of a human knee joint were created with the collagen architectures obtained from T2 mapped MRI (patient-specific model) and from literature (literature model). The effect of accuracy of the implementation of collagen fibril architecture into the model was examined by using a submodel with denser FE mesh. Compared to the literature model, fibril strains and maximum principal stresses were reduced especially in the superficial/middle regions of medial tibial cartilage in the patient-specific model after the loading response of gait (up to -413 and -26%, respectively). Compared to the more coarsely meshed joint model, the patient-specific submodel demonstrated similar strain and stress distributions but increased values particularly in the superficial cartilage regions (especially stresses increased >60%). The results demonstrate that implementation of subject-specific collagen architecture of cartilage in 3-D modulates location- and time-dependent mechanical responses of human knee joint cartilage. Submodeling with more accurate implementation of collagen fibril architecture alters cartilage stresses particularly in the superficial/middle tissue.

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Source
http://dx.doi.org/10.1080/10255842.2015.1124269DOI Listing

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