The present study deals with preparation and optimization of a novel chitosan hydrogel-based matrix by suspension cross-linking method for controlled release of Depo-Medrol. The controlled release of Depo-Medrol for effective Rheumatoid arthritis disease has become an imperative field in the drug delivery system. In this context, it was intended to optimize loading circumstances by experimental design and also study the release kinetics of Depo-Medrol entrapped in the chitosan matrix in order to obtain maximal efficiency for drug loading. The optimum concentrations of chitosan (2.5 g), glutaraldehyde (3.05 μL) and Depo-Medrol (0.1 mg) were set up to achieve the highest value of drug loaded and the most sustained release from the chitosan matrix. In vitro monitoring of drug release kinetic using high-performance liquid chromatography showed that 73% of the Depo-Medrol was released within 120 min, whereas remained drug was released during the next 67 h. High correlation between first-order and Higuchi's kinetic models indicates a controlled diffusion of Depo-Medrol through the surrounding media. Moreover, recovery capacity >82% and entrapment efficiency of 58-88% were achieved under optimal conditions. Therefore, the new synthesized Depo Medrol-chitosan is an applicable appliance for arthritis therapy by slow release mechanism. Copyright © 2016 John Wiley & Sons, Ltd.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/bmc.3679 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Organic-Free Synthesis of High-Silica Zeolite Y with Aluminophosphate as the Aluminum Carrier.
Angew Chem Int Ed Engl
January 2025
Nanjing Tech University, College of Chemical Engineering, Nanjing, CHINA.
The wide application of zeolite Y in petrochemical industry is well known as one of the milestones in zeolite chemistry and heterogeneous catalysis. However, the traditional organic-free synthesis typically produces (hydro)thermally unstable zeolite Y with Si/Al atomic ratio (SAR) less than 2.5.
View Article and Find Full Text PDFDeamination mechanism of modified magnesium slag using wet aging and its performance evolution as backfill material.
J Environ Manage
January 2025
School of Business, Xi'an University of Finance and Economics, Xi'an, 710100, China.
The purpose of this study is to solve the problem of ammonia (NH) release when modified magnesium slag (MMS) is used as coal mine backfill cementitious material, and to explore its chemical mechanism and put forward effective solutions. Uniaxial compressive strengths (UCS) hydration kinetics, scanning electron microscope (SEM), and thermogravimetric analysis-derivative thermogravimetry (TG-DTG), X-ray diffractometer (XRD) and other testing methods were used to study the evolution of the properties of MMS-based backfill material, which provided a scientific basis for the safe utilization of MMS. First, the chemical mechanism underlying the release of NH from MMS was identified, and it was confirmed that MgN and LiN are the main nitrogen sources.
View Article and Find Full Text PDFPeptide-Based Complex Coacervates Stabilized by Cation-π Interactions for Cell Engineering.
J Am Chem Soc
January 2025
Center for Sustainable Materials (SusMat), School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Complex coacervation is a form of liquid-liquid phase separation, whereby two types of macromolecules, usually bearing opposite net charges, self-assemble into dense microdroplets driven by weak molecular interactions. Peptide-based coacervates have recently emerged as promising carriers to deliver large macromolecules (nucleic acids, proteins and complex thereof) inside cells. Thus, it is essential to understand their assembly/disassembly mechanisms at the molecular level in order to tune the thermodynamics of coacervates formation and the kinetics of cargo release upon entering the cell.
View Article and Find Full Text PDFUnderstanding the interaction between selected microplastics and the toxic dye "Congo red" in water.
Chemosphere
January 2025
DASCO Inc, Centennial, Colorado, USA.
This study thoroughly investigated the adsorption of Congo Red (CR) dye onto various microplastics (MPs), including high-density polyethylene (HDPE), polyvinyl chloride (PVC), low-density polyethylene (LDPE), polypropylene (PP) and polyethylene terephthalate (PET). Initial adsorption capacities (q) revealed that HDPE had the highest value (21.90 mg/g), followed by PVC (4.
View Article and Find Full Text PDFIn situ remediation of oil-contaminated soils by ozonation: Experimental study and numerical modeling.
Chemosphere
January 2025
Institute of Chemical Engineering Sciences, Foundation for Research and Technology Hellas (FORTH/ICE-HT), 26504, Patras, Greece. Electronic address:
The goal of the present work is to quantify the performance of ozonation as a method for the in situ remediation of soils polluted at varying degree with different types of hydrocarbons, and assess its applicability, in terms of remediation efficiency, cost factors, and environmental impacts. Ozonation tests are conducted on dry soil beds, for three specific cases: sandy soil contaminated with low, moderate and high concentration of a non-aqueous phase liquid (NAPL) consisting of equal concentrations of n-decane, n-dodecane, and n-hexadecane; sandy soil polluted with diesel fuel; oil-drilling cuttings (ODC). The transient changes of the concentration of the total organic carbon (TOC), total petroleum hydrocarbons (TPH), polycyclic aromatic hydrocarbons (PAHs), and soluble chemical oxygen demand (SCOD) in soil and carbon dioxide (CO), carbon monoxide (CO), volatile organic compounds (VOCs), and ozone (O) in exhaust gases are recorded.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!