Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6.

Bioorg Med Chem Lett

Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, J&K 180001, India. Electronic address:

Published: January 2016

A library of boswellic acid analogues were synthesized and tested for their anti-inflammatory potential on key inflammatory mediators, TNF-α and IL-6. The study led to the identification of lead compounds showing significant inhibition of the cytokines, TNF-α and IL-6 both in vitro and in vivo.

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http://dx.doi.org/10.1016/j.bmcl.2015.11.035DOI Listing

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