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Exosome-delivered NR2F1-AS1 and NR2F1 drive phenotypic transition from dormancy to proliferation in treatment-resistant prostate cancer via stabilizing hormonal receptors.
J Nanobiotechnology
December 2024
Department of Urology, Guangzhou Women and Children's Medical Center, National Children's Medical Center for South Central Region, Guangzhou Medical University, Guangzhou, Guangdong, China.
Cancer cells acquire the ability to reprogram their phenotype in response to targeted therapies, yet the transition from dormancy to proliferation in drug-resistant cancers remains poorly understood. In prostate cancer, we utilized high-plasticity mouse models and enzalutamide-resistant (ENZ-R) cellular models to elucidate NR2F1 as a key factor in lineage transition and ENZ resistance. Depletion of NR2F1 drives ENZ-R cells into a relative dormancy state, characterized by reduced proliferation and heightened drug resistance, while NR2F1 overexpression yields contrasting outcomes.
View Article and Find Full Text PDFMyelomatous pleural effusion (MPE) is a rare, often treatment-resistant complication of multiple myeloma. Intrapleural bortezomib shows promise but lacks standardized dosing. We report a 62-year-old woman with MPE treated with 1.
View Article and Find Full Text PDFTreatment-Resistant Chromoblastomycosis Successfully Managed With Surgical Excision.
Cureus
November 2024
Dermatology, University of California Davis Medical Center, Sacramento, USA.
Chromoblastomycosis is an uncommon, chronic granulomatous fungal infection of the skin and subcutaneous tissue. Chromoblastomycosis is most commonly caused by the traumatic inoculation of dematiaceous (pigmented) fungi, most commonly species, species, and species. Chromoblastomycosis usually affects agricultural workers in tropical and subtropical climates.
View Article and Find Full Text PDFDifferentiating Glioma Recurrence and Pseudoprogression by APTw CEST MRI.
Invest Radiol
December 2024
From the Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany (K.K.-J., N.E., E.G., K.S., J.U., H.F.-P., D.S., V.S., J.M.K., I.P., S.H., M.B., M.O.B.); Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany (K.K.-J., F.W., W.W.); Department of Neurology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany (D.B., F.M.I., F.W., W.W.); DKTK, DKFZ, Clinical Cooperation Unit Neuropathology, Heidelberg, Germany (F.M.I.); Division of Radiology, DKFZ, Heidelberg, Germany (N.V., D.P.); Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKTK, DKFZ, Heidelberg, Germany (L.B., M.P., M.O.B.); Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany (L.B., M.P.); Division of Neuroradiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.P.); and Clinic for Neuroradiology, University Hospital Bonn, Bonn, Germany (D.P.).
Objectives: Recurrent glioma is highly treatment resistant due to its metabolic, cellular, and molecular heterogeneity and invasiveness. Tumor monitoring by conventional MRI has shortcomings to assess these key glioma characteristics. Recent studies introduced chemical exchange saturation transfer for metabolic imaging in oncology and assessed its diagnostic value for newly diagnosed glioma.
View Article and Find Full Text PDFA case of gastric/duodenal diffuse large B cell lymphoma observed during the administration of tacrolimus/azathioprine for dermatomyositis.
Clin J Gastroenterol
December 2024
Division of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, 162-8666, Japan.
The patient was diagnosed with amyopathic dermatomyositis complicated with interstitial pneumonia (IP) at age 35. She had been treated with prednisolone and maintained on tacrolimus (TAC) + azathioprine (AZA). Eight years later, she experienced epigastric pain, and esophagogastroduodenoscopy (EGD) led to a diagnosis of duodenal ulcer.
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