[Investigation of bone loss and its related factors in renal transplant recipients].

Objective: To investigate the incidence and analyze the factors related to bone loss after renal transplantation, in order to guide the intervention of it.

Methods: We picked up 263 cases of renal transplantation outpatients with well graft function from February to May 2014 according to random number table. Bone mineral density (BMD) were examined by quantitative ultrasound and other demographic information and clinical data were collected. According to the diagnostic criteria of the osteoporosis established by WHO, the selected patients were divided into osteoporosis group (n = 62) and normal group (n = 63), univariate analysis and Logistic regression analysis were used to determine related factors responsible for bone loss after renal transplantation.

Results: The percentage of bone loss in renal transplant recipients was 76. 05% (200/263). Logistic regression analysis revealed the risk factors of osteoporosis in renal transplant recipients were age older than 50 years old (P = 0. 01), parent fractured hip history (P = 0. 00), high dose of corticosteroid (P = 0. 02). Compared with those not being treated with calcitriol, patients intake calcitriol see 8. 80% decreased incidence of bone loss.

Conclusions: A high incidence of bone loss is found in renal transplant recipients. Age, parent fractured hip history, corticosteroid dose are related factors of osteoporosis in renal transplant recipients. Calcitriol is effective in preventing and treating bone loss in renal transplant recipients.