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Chemopreventive effect of Pistacia vera leaf extract against mammary carcinoma induced by dimethyl-benz(a)anthracene in vivo and in vitro: Potential role of antioxidant, antiinflammatory and immune mechanisms.
Food Chem Toxicol
January 2025
Zoology Department, Faculty of Science, Al-Azhar University, 71524, Assuit, Egypt.
This study aimed to define the antitumor effect of ethanolic extract of Pistacia vera leaves (PEE) toward breast cancer both in vitro and in vivo using dimethyl-benz(a)anthracene (DMBA)-induced breast tumor in adult female rats. PEE showed a potent antioxidant effect toward both DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radicals with IC values of 72.6 and 107.
View Article and Find Full Text PDFFracture incidence in women: the impact of reproductive characteristics.
BMC Public Health
December 2024
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 24 Parvaneh St., Yaman St., Velenjak, PO Box 19395-4763, Tehran, Iran.
Article Synopsis
- The study investigates how reproductive factors (RFs) like age at menarche, number of births, and duration of breastfeeding affect the risk of fractures in women.
- It followed a cohort of women from 1999 to 2021, finding that 3.3% experienced fractures during the study period, while adjusting for confounders.
- Results indicated that more childbirths and older age at menarche increase fracture risk, while longer exclusive breastfeeding decreases it.
Unlabelled: Focal adhesion kinase (FAK) functions as a signaling and scaffolding protein within endothelial cells (ECs) impacting blood vessel function and tumor growth. Interpretations of EC FAK-null phenotypes are complicated by related PYK2 (protein tyrosine kinase 2) expression, and to test this, we created PYK2 FAK mice with tamoxifen-inducible EC-specific Cre recombinase expression. At 11 weeks of age, EC FAK inactivation resulted in increased heart and lung mass and vascular leakage only on a PYK2 background.
View Article and Find Full Text PDFRisk Factors for Acute Intraoperative Bradycardia in Patients Undergoing Gender-affirming Mastectomy.
Plast Surg (Oakv)
October 2024
Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health. Madison, WI, USA.
Gender-affirming mastectomy surgery is highly desired within both transmasculine and nonbinary patient populations. The development of cardiac arrhythmias has been reported within this population. Acute intraoperative bradycardia in patients undergoing gender-affirming mastectomy has not been well described previously.
View Article and Find Full Text PDFOnline Misleading Information About Women's Reproductive Health: A Narrative Review.
J Gen Intern Med
November 2024
, Critica, Bronx, NY, USA.
Misinformation about reproductive health threatens to harm health outcomes, compromise medical trust, and enable misinformed policy restrictions. In recent years, reproductive health misinformation has proliferated online due to ideological campaigns and limited content moderation for reproductive health topics. Developing evidence-based practices to counter reproductive health misinformation requires an understanding of the content that women are exposed to online, which is currently lacking.
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