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Mechanisms of Resistance to Rituximab Used for the Treatment of Autoimmune Blistering Diseases.
Life (Basel)
September 2024
Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 1, 020021 Bucharest, Romania.
Autoimmune blistering diseases represent a group of chronic severe, disabling, and potentially fatal disorders of the skin and/or mucous membranes, primarily mediated by pathogenic auto-antibodies. Despite their rarity, these diseases are associated with significant morbidity and mortality and profound negative impact on the patient's quality of life and impose a considerable economic burden. Rituximab, an anti-CD-20 monoclonal antibody, represents the first line of therapy for pemphigus, regardless of severity and a valuable off-label therapeutic alternative for subepidermal autoimmune blistering diseases as it ensures high rates of rapid, long-lasting complete remission.
View Article and Find Full Text PDFKey Biophysical and Physiological Properties Impacting the Oxygenation Status of Breast Cancers During Thermo-radiotherapy.
Adv Exp Med Biol
October 2024
Department of Radiation Oncology, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany.
Article Synopsis
- Mild hyperthermia (39-43 °C) is used locoregionally for 30-60 minutes to enhance oxygenation in recurrent breast cancers, which can improve the effectiveness of various treatments like radiotherapy, chemotherapy, and immunotherapy.!* -
- Data from clinical trials and experiments show that breast cancer tissue generally has higher water content and density compared to normal breast tissue, and these values increase during mild hyperthermia.!* -
- Key factors affecting oxygenation in both healthy and cancerous breast tissue include blood flow, interstitial fluid dynamics, and tissue permeability, with most parameters improving under mild hyperthermia treatment.!*
Successfully Nonsurgical Epidermoid Cyst Management with Recombinant Hydrolytic Enzymes: A Case Report.
Clin Cosmet Investig Dermatol
August 2024
Universidad Simón Bolívar. Facultad de Ciencias de la Salud, Centro de Investigaciones de Ciencias de la Vida (CICV), Barranquilla, Colombia.
Article Synopsis
- Epidermoid cysts (E.C.s) are benign lumps filled with keratin that can develop when hair follicle openings become blocked, traditionally treated through surgical methods with good outcomes.
- A case study of a 44-year-old woman with a long-standing E.C. on her cheek showed successful treatment through a less invasive method using enzyme injections, leading to significant improvement within three weeks and complete resolution in 40 days.
- This new enzyme injection technique may offer a promising alternative to surgery for E.C.s, but more research is needed to establish its safety and effectiveness.
Acral persistent papular mucinosis: a rare child case report and literature review.
Transl Pediatr
June 2024
Department of General Surgery, Tianjin Children's Hospital (Children's Hospital, Tianjin University), Tianjin, China.
Background: Acral persistent papular mucinosis (APPM) is a rare idiopathic subtype of localized lichen myxedematosus. To date, there have been less than 41 APPM cases reported worldwide, however, almost all patients were older than 18 years of age. A 7-year-old child was first reported in this paper.
View Article and Find Full Text PDFGranular C3 dermatosis-A report of two cases and a mini-review of literature.
J Dermatol
December 2024
Department of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Article Synopsis
- - Granular C3 dermatosis (GCD) presents with skin lesions similar to dermatitis herpetiformis and is characterized by the deposition of complement C3 and C5b-9 at the epidermal basement membrane zone, as seen in direct immunofluorescence tests.
- - Two cases of GCD highlighted different symptoms: a 49-year-old man with itchy blisters and a 53-year-old woman with widespread pruritic papules and blisters, both showing eosinophilia and specific histopathological features.
- - Treatment for GCD included topical steroids and oral medications for the first patient with success, while the second patient improved with oral steroids but had some lingering symptoms; overall awareness and
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