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Diffuse Alveolar Hemorrhage Associated With Anti-PL-7 Antisynthetase Syndrome: A Case Report.
Case Rep Pulmonol
January 2025
Prisma Health, University of South Carolina-School of Medicine, Columbia, South Carolina, USA.
Diffuse alveolar hemorrhage (DAH) is a potentially life-threatening condition which can present with hemoptysis, diffuse alveolar infiltrates, anemia, and hypoxic respiratory failure. Antisynthetase syndrome (AS) is a rare autoimmune disorder most often characterized by nonerosive arthritis, proximal muscle weakness with elevated muscle enzymes, Raynaud's phenomenon, hyperkeratosis of the digits (mechanic's hands), and interstitial lung disease. According to large population studies, AS has an annual incidence of 0.
View Article and Find Full Text PDFClinical features and prognosis of anti-MDA5-positive dermatomyositis with coexistent anti-aminoacyl-tRNA synthetase antibodies.
Clin Rheumatol
February 2025
Department of Rheumatology and Immunology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Objectives: This study aimed to evaluate the incidence and clinical significance of coexistence of anti-aminoacyl-tRNA synthetase (anti-ARS) antibody in patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis (anti-MDA5 + DM).
Methods: We assessed a cohort of 246 consecutive patients with anti-MDA5 + DM. Clinical characteristics and survival rates were compared between patients with and without anti-ARS antibodies.
Article Synopsis
- - The study focused on anti-synthetase syndrome (ASSD), a rare autoimmune disease, aiming to identify clinical and lab features for potential classification criteria.
- - Researchers analyzed data from 948 ASSD patients and 1077 control subjects, finding that certain symptoms like arthritis and specific autoantibodies were more common in ASSD cases.
- - The findings will assist clinicians in diagnosing ASSD and contribute to creating more standardized, data-driven classification criteria for the syndrome.
Favorable Response to Adjuvant Tofacitinib in a Case of Anti-Melanoma Differentiation-Associated Gene-5 Antibody Positive Clinically Amyopathic Dermatomyositis.
Indian Dermatol Online J
April 2024
Department of Respiratory Medicine, GCS Medical College, Hospital and Research Centre, Ahmedabad, Gujarat, India.
Article Synopsis
- A case study discusses a 38-year-old female with clinically amyopathic dermatomyositis (CADM) displaying symptoms like vasculopathic ulcers, mechanic's hands, and interstitial lung disease (ILD).
- *Her diagnosis included normal muscle enzyme levels and the presence of specific antibodies (anti-Mi2 and anti-MDA-5) confirmed through immunoblotting.
- *Following an inadequate response to standard treatments, the addition of tofacitinib, which inhibits the JAK-STAT pathway and type 1 interferon, resulted in significant improvement in her skin and lung condition over six months.
[Translated article] Mechanic's Hands: Clinical and Histopathologic Findings.
Actas Dermosifiliogr
September 2024
Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, Spain.
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