AI Article Synopsis
- Lipopolysaccharides (LPS) can trigger excessive immune responses that may worsen sickness and depression.
- The study identified stigmasta-3,5-dien-7-one (ST) from Phragmitis rhizoma as an anti-inflammatory agent that reduces key inflammatory markers elevated by LPS.
- ST works by inhibiting the NF-κB signaling pathway, which is involved in inflammation, making this the first research to document its potential anti-inflammatory properties.
Article Abstract
Lipopolysaccharides (LPS) strongly stimulate immune cells, and unabated activation of immune system by LPS may lead to an exacerbation of sickness and depression. In this study, stigmasta-3,5-dien-7-one (ST) was isolated from Phragmitis rhizoma as a negative regulator of LPS-induced inflammation in macrophages. ST effectively reduced nitric oxide (NO), prostaglandin E2, and pro-inflammatory cytokine levels, which were markedly raised by LPS treatment. In addition, ST blocked the nuclear factor-kappa B (NF-κB) signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of the inhibitor of NF-κB α. To our knowledge, this is the first study showing anti-inflammatory activities of ST isolated from Phragmitis rhizoma.
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| http://dx.doi.org/10.1007/s10753-015-0299-6 | DOI Listing |
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