Hemozoin Detection for Human Malaria Diagnosis Investigated in Rodent Models: How Similar Is Similar?

Trends Parasitol

Center for Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, PO Box 22660, Amsterdam, DD 1100 The Netherlands.

Published: February 2016

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Article Abstract

New malaria diagnostic methods based on hemozoin (Hz) detection have been reported recently and were investigated in rodent models. These models are likely to produce unduly favorable results compared to the reality of Plasmodium falciparum malaria. Thus, for malaria diagnostics, results from rodent malaria experiments must be interpreted with caution.

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http://dx.doi.org/10.1016/j.pt.2015.11.012DOI Listing

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