AI Article Synopsis
- Duchenne Muscular Dystrophy (DMD) is a severe genetic disease leading to muscle degeneration with no current cure, heavily impacting energy balance in muscles.
- The disease is linked to inherent defects in energy systems that contribute to muscle wasting.
- Research is focusing on nutriceuticals and metabolic compounds that may improve energy production and potentially slow down disease progression in DMD.
Article Abstract
Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no current cure. A prominent, yet poorly treated feature of dystrophic muscle is the dysregulation of energy homeostasis which may be associated with intrinsic defects in key energy systems and promote muscle wasting. As such, supplementative nutriceuticals that target and augment the bioenergetical expansion of the metabolic pathways involved in cellular energy production have been widely investigated for their therapeutic efficacy in the treatment of DMD. We describe the metabolic nuances of dystrophin-deficient skeletal muscle and review the potential of various metabogenic and nutriceutical compounds to ameliorate the pathological and clinical progression of the disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690050 | PMC |
| http://dx.doi.org/10.3390/nu7125498 | DOI Listing |
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