Chromatin domains associated with the nuclear lamina are generally heterochromatic and transcriptionally repressed. How they are recruited to and maintained at the nuclear periphery remains unclear. A recent study by Gonzalez-Sandoval et al. (2015) in Cell identifies a chromatin-binding protein that links repressive chromatin with the inner nuclear membrane.
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| http://dx.doi.org/10.1016/j.devcel.2015.12.007 | DOI Listing |
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