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Background: Acne is an inflammatory skin disease afflicting the majority of the world's population at some point in their lifetime, and is seen to be chronic in about 50% of cases. Acne leads to significant social withdrawal, depression, and disfiguring scars in many cases. Available treatments are characterized by high rates of relapse, dangerous side effects, and social stigma, which often leads to poor patient compliance and treatment failure.
View Article and Find Full Text PDFUse of Interleukin-12/23 Inhibitor for the Management of Acne Fulminans.
Cureus
December 2023
Dermatology, Oakview Dermatology, Athens, USA.
Article Synopsis
- Acne fulminans (AF) is a rare and severe skin disorder that causes painful nodules and ulcers, primarily affecting adolescent males with a history of acne.
- * The condition is often associated with isotretinoin therapy and high testosterone levels, but its exact cause is unknown. Standard treatments include corticosteroids and isotretinoin.
- * In a reported case, a 17-year-old male with AF did not respond to these treatments but improved significantly when treated with ustekinumab, allowing for a reduction in corticosteroids and an increase in isotretinoin dosage.*
Pityriasis Rubra Pilaris: An Updated Review of Clinical Presentation, Etiopathogenesis, and Treatment Options.
Am J Clin Dermatol
March 2024
Department of Dermatology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Pityriasis rubra pilaris (PRP) is a rare papulosquamous reaction pattern with a significant impact on quality of life. Type I PRP is the most common PRP variant, presenting as erythematous papules emerging in a follicular distribution and later coalescing into plaques with characteristic islands of sparing; histologically, an alternating pattern of orthokeratosis and parakeratosis is considered the hallmark of PRP (checkerboard hyperkeratosis). Other PRP variants (types II-V) differ in their age of onset and clinical presentation.
View Article and Find Full Text PDFThe Impact of I-Metaiodobenzylguanidine as a Conditioning Regimen of Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for High-Risk Neuroblastoma.
Children (Basel)
December 2023
Department of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Background: The optimal conditioning regimen of tandem high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) for high-risk neuroblastoma (HR-NBL) has not been established. The efficacy of I-MIBG therapy is under exploration in newly diagnosed HR-NBL patients. Here, we compared the outcomes of tandem HDC/ASCT between the I-MIBG combination and non-MIBG groups.
View Article and Find Full Text PDFEffects of oral isotretinoin treatment for acne vulgaris patients on anger responses and the relationship with temperament.
Rev Assoc Med Bras (1992)
December 2023
Department of Dermatology and Venereology - İstanbul, Turkey.
Objective: Isotretinoin is the only medication against all the factors involved in acne vulgaris pathogenesis. The aim of our study was to verify whether patients with acne vulgaris receiving isotretinoin therapy exhibit elevated anger levels and to observe the correlation between age, temperament traits, and anger.
Methods: The study group comprised a sum of 100 cases, involving 50 individuals with acne vulgaris-required high-dose retinol therapy and 50 controls who did not start any medication.
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