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The GD-1 Stellar Stream Perturber as a Core-collapsed Self-interacting Dark Matter Halo.
Astrophys J Lett
January 2025
Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101, USA;
The GD-1 stellar stream exhibits spur and gap structures that may result from a close encounter with a dense substructure. When interpreted as a dark matter subhalo, the perturber is denser than predicted in the standard cold dark matter (CDM) model. In self-interacting dark matter (SIDM), however, a halo could evolve into a phase of gravothermal collapse, resulting in a higher central density than its CDM counterpart.
View Article and Find Full Text PDFHeat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments.
Int J Biol Sci
January 2025
Department of Otolaryngology Head and Neck Surgery/Deep Underground Space Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Heat acclimation (HA) is an evolutionarily conserved trait that enhances tolerance to novel stressors by inducing heat shock proteins (HSPs). However, the molecular mechanisms underlying this phenomenon remain elusive. In this study, we established a HA mouse model through intermittent heat stimulation.
View Article and Find Full Text PDFLncRNA Expression Profiles in C6 Ceramide Treatment Reveal lnc_025370 as a Promoter in Canine Mammary Carcinoma CHMp Cells Progression.
Curr Issues Mol Biol
December 2024
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Canine mammary carcinomas (CMCs) represent the most prevalent form of cancer in female dogs, characterized by a high incidence and mortality rate. C6 ceramide is recognized for its multifaceted anti-cancer properties, yet its specific influence on CMCs remains to be elucidated. Long noncoding RNAs (lncRNAs), now recognized as functional "dark matter" in precision oncology, are particularly intriguing, with 44% of canine lncRNAs exhibiting tissue-specific expression.
View Article and Find Full Text PDFFrom Gene to Structure: Unraveling Genomic Dark Matter in . Accumulibacter.
Environ Sci Technol
January 2025
School of Environment and Energy, South China University of Technology, Guangzhou 510006, China.
" Accumulibacter" is a unique and pivotal genus of polyphosphate-accumulating organisms prevalent in wastewater treatment plants and plays mainstay roles in the global phosphorus cycle. However, the efforts to fully understand their genetic and metabolic characteristics are largely hindered by major limitations in existing sequence-based annotation methods. Here, we reported an integrated approach combining pangenome analysis, protein structure prediction and clustering, and meta-omic characterization, to uncover genetic and metabolic traits previously unexplored for .
View Article and Find Full Text PDFA universe of human gut-derived bacterial prophages: unveiling the hidden viral players in intestinal microecology.
Gut Microbes
December 2024
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, P. R China.
Prophages, which are an existing form of temperate phages that integrate into host genomes, have been found extensively present in diverse bacterial species. The human gut microbiome, characterized by its complexity, dynamism, and interconnectivity among multiple species, remains inadequately understood in terms of the global landscape of bacterial prophages. Here, we analyzed 43,942 human gut-derived bacterial genomes (439 species of 12 phyla) and identified 105,613 prophage regions in ~ 92% of them.
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