AI Article Synopsis
- The exact cause of systemic sclerosis is still unclear, but immune cells, particularly macrophages and monocytes, might play a key role in starting or maintaining the disease.
- These immune cells are categorized into two types: the pro-inflammatory M1 phenotype and the pro-fibrotic/anti-inflammatory M2 phenotype.
- This review focuses on significant research that explores how these macrophages and monocytes contribute to the development of systemic sclerosis.
Article Abstract
The pathogenesis of systemic sclerosis is still unknown, although immune cells, mainly macrophages/monocytes, may have an important role in initiating and/or perpetuating the disease. Macrophages and monocytes are often classified as pro-inflammatory M1 phenotype or classic activation and pro-fibrotic/anti-inflammatory M2 phenotype or alternative activation. In this review, we highlighted the most relevant research regarding the involvement of macrophages/monocytes in the pathogenesis of this complex disease.
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| http://dx.doi.org/10.1007/s11926-015-0554-8 | DOI Listing |
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