We studied the results and stability of Le Fort I maxillary osteotomies with advancement of at least 1cm. We analysed prospective data from 32 consecutive patients who were operated on by a single surgeon between 1985 and 2007, and who had mean advancement of the maxilla of 14 mm (range 10-22 mm). Mean relapse for all cases antero-posteriorly was 1mm, 10% (range 0-4mm). Relapse was marginally greater in the 24 patients with a repaired cleft palate (11%) compared with those without a cleft (8%). The results were essentially stable at least one year after surgery and without significant complications. This study indicates that Le Fort I osteotomies of 1cm or more carried out in the way described are safe and stable.
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http://dx.doi.org/10.1016/j.bjoms.2015.09.025 | DOI Listing |
Alzheimers Dement
December 2024
Colorado State University, Fort Collins, CO, USA.
Background: In tauopathies, the protein tau misfolds into a b-sheet conformation that self-templates and spreads throughout the brain causing progressive degeneration. Biological and structural data have shown that the shape, or strain, that tau adopts when it misfolds determines which disease a patient will develop. We previously used HEK293T cells expressing TauRD-YFP to show that tau strain formation is isoform-specific.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Manitoba, Winnipeg, MB, Canada.
Background: Mitochondrial bioenergetics are essential for cellular function, specifically the intricacies of the electron transport chain (ETC), with Complex IV playing a crucial role in unraveling the mechanisms governing energy production. Mathematical models offer a valuable approach to simulate these complex processes, providing insights into normal mitochondrial function and aberrations associated with various diseases, including neurodegenerative disorders. Our research focuses on introducing and refining a mathematical model, emphasizing Complex IV in the ETC, with objectives including incorporating mitochondrial activity modulation using inhibiting and uncoupling reagents, akin to oxygen consumption experiments.
View Article and Find Full Text PDFJ Craniofac Surg
January 2025
Division of Pediatric Craniofacial Surgery, Nemours Children's Health, Jacksonville, FL.
External rigid distraction is an established method for achieving subcranial Le Fort III advancement in severe syndromic craniosynostosis. Craniofacial surgeons commonly use halo-type devices for these corrections, as they allow for multiple vectors of pull and facilitate larger midfacial advancements. Although most complications related to their use involve pin displacement or infection, rare complications such as skull fractures have been reported.
View Article and Find Full Text PDFCureus
December 2024
Microbiology and Immunology, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, USA.
Introduction: The presence of female faculty members in anesthesia residency programs is pivotal for enhancing and supporting diversity and gender equity in medical education. This study probes the intricate interplay between the percentage of female faculty and whether program type and geographical location impact the composition of female faculty.
Methods: For this retrospective cross-sectional analysis, we collected data from the Fellowship and Residency Electronic Interactive Database Access (FREIDA) system to assess the percentages of female faculty in anesthesia residency programs.
Vet Comp Oncol
January 2025
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Colorado, Fort Collins, US.
Body composition measurements (BCM), obtained via computed tomography (CT), have been used as predictors of survival, tumour recurrence, and post-surgical infections in human oncology. There are no reports on using BCM to predict outcomes of dogs with cancer. Elevated BCM is hypothesised to place extra stress on bones weakened by cancer.
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