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Adaptive Laboratory Evolution Uncovers Potential Role of a DNA Helicase Mutation in Torulaspora delbrueckii Increased Sulphite Resistance.
Environ Microbiol
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Department of Biology, CBMA (Centre of Molecular and Environmental Biology), University of Minho, Braga, Portugal.
Wine industry has faced pressure to innovate its products. Saccharomyces cerevisiae has been the traditional yeast for producing alcoholic beverages, but interest has shifted from the conventional S. cerevisiae to non-Saccharomyces yeasts for their biotechnological potential.
View Article and Find Full Text PDFEvolution and diversification of the momilactone biosynthetic gene cluster in the genus Oryza.
New Phytol
January 2025
Faculty of Biology, Ludwig-Maximilians-Universität München, 82152, Martinsried, Germany.
Plants are master chemists and collectively are able to produce hundreds of thousands of different organic compounds. The genes underlying the biosynthesis of many specialized metabolites are organized in biosynthetic gene clusters (BGCs), which is hypothesized to ensure their faithful coinheritance and to facilitate their coordinated expression. In rice (Oryza sativa), momilactones are diterpenoids that act in plant defence and various organismic interactions.
View Article and Find Full Text PDFMitochondrial DNA copy number alterations: Key players in the complexity of glioblastoma (Review).
Mol Med Rep
March 2025
Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.
Renowned as a highly invasive and lethal tumor derived from neural stem cells in the central nervous system, glioblastoma (GBM) exhibits substantial histopathological variation and genomic complexity, which drive its rapid progression and therapeutic resistance. Alterations in mitochondrial DNA (mtDNA) copy number (CN) serve a crucial role in GBM development and progression, affecting various aspects of tumor biology, including energy production, oxidative stress regulation and cellular adaptability. Fluctuations in mtDNA levels, whether elevated or diminished, can impair mitochondrial function, potentially disrupting oxidative phosphorylation and amplifying reactive oxygen species generation, thereby fueling tumor growth and influencing treatment responses.
View Article and Find Full Text PDFA unique feature of Oxford Nanopore Technologies sequencers, adaptive sampling, allows precise DNA molecule selection from sequencing libraries. Here we present enhancements to our tool, readfish, enabling all features for the industrial scale PromethION sequencer, including standard and "barcode-aware" adaptive sampling. We demonstrate effective coverage enrichment and assessment of multiple human genomes for copy number and structural variation on a single PromethION flow cell.
View Article and Find Full Text PDFCurrent progress and future perspectives in personal identification of monozygotic twins in forensic medicine.
Forensic Sci Int Genet
January 2025
School of Forensic Medicine, China Medical University, Shenyang, PR China; Key Laboratory of Forensic Bio-evidence Sciences, Shenyang, Liaoning Province PR China; China Medical University Center of Forensic Investigation, Shenyang, PR China; Shanghai Key Laboratory of Forensic Medicine and Key Laboratory of Forensic Science, Ministry of Justice, PR China. Electronic address:
The personal identification of monozygotic (MZ) twins is of great importance in forensic medicine. Due to the extreme similarity in genetic between MZ twins, it is challenging to differentiate them using autosomal STR genotyping. Forensic experts are striving to explore available genetic markers that can differentiate between MZ twins.
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