The pharmacokinetic (PK) profile of nicotine delivered by an Electronic Vapour Product (EVP) was characterised in a 2-part study in smokers. The study was designed as a randomised, controlled, four-way crossover trial. Part 1 compared an unflavoured e-liquid (UF2.0%) and a flavoured e-liquid (FL2.0%) to a conventional cigarette (CC; JPS Silver King Size, 0.6 mg) and a licensed nicotine inhalator (Nicorette(®); 15 mg). Part 2 compared e-liquids with increasing nicotine concentrations (0%, 0.4%, 0.9%, 2.0%). Subjects used each different product for a daily use session. In Part 1, maximum plasma nicotine concentration (Cmax) for UF2.0%, FL2.0%, Nicorette(®) and CC was 3.6, 2.5, 2.5 and 21.2 ng/mL, respectively. The time to maximum plasma nicotine concentration (Tmax) was longer for the EVP (UF2.0%, 9.0 min; FL2.0%, 10.0 min) and the nicotine inhalator (13.0 min) compared to CC (3.0 min). In Part 2, EVP with 0%, 0.4%, 0.9% and 2.0% nicotine produced Cmax values of 0.6, 1.0, 1.9 and 3.6 ng/mL, respectively. At the maximum nicotine concentration of 2% as prescribed by the European Tobacco Directive, the EVP achieved nicotine delivery that was comparable to the inhalator. EVPs thus offer a potential alternative to nicotine inhalator devices for those finding it difficult to quit smoking.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.yrtph.2015.12.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A comprehensive retrospect on the current perspectives and future prospects of pneumoconiosis.
Front Public Health
January 2025
Environmental Exposures Vascular Disease Institute, Shanxi Medical University, Taiyuan, Shanxi, China.
Pneumoconiosis is a widespread occupational pulmonary disease caused by inhalation and retention of dust particles in the lungs, is characterized by chronic pulmonary inflammation and progressive fibrosis, potentially leading to respiratory and/or heart failure. Workers exposed to dust, such as coal miners, foundry workers, and construction workers, are at risk of pneumoconiosis. This review synthesizes the international and national classifications, epidemiological characteristics, strategies for prevention, clinical manifestations, diagnosis, pathogenesis, and treatment of pneumoconiosis.
View Article and Find Full Text PDFPregnancy and Postpartum Effects of Electronic Cigarettes on Maternal Health and Vascular Function in the Fourth Trimester.
Cardiovasc Toxicol
January 2025
Department of Physiology, Pharmacology and Toxicology, West Virginia University School of Medicine, Morgantown, WV, USA.
Pregnancy is a vulnerable time with significant cardiovascular changes that can lead to adverse outcomes, which can extend into the postpartum window. Exposure to emissions from electronic cigarettes (Ecig), commonly known as "vaping," has an adverse impact on cardiovascular function during pregnancy and post-natal life of offspring, but the postpartum effects on maternal health are poorly understood. We used a Sprague Dawley rat model, where pregnant dams are exposed to Ecigs between gestational day (GD)2-GD21 to examine postpartum consequences.
View Article and Find Full Text PDFEffect of electronic cigarette atomising power and flavour on aerosol size-segregated metal concentration and inhalation risk.
Tob Control
January 2025
Department of Epidemiology and Biostatistics, Temple University College of Public Health, Philadelphia, Pennsylvania, USA
Introduction: Although numerous studies have estimated the inhalation dose of metals emitted from electronic cigarettes (e-cigs), the impact of factors including aerosol size and the atomising power of e-cig aerosols on estimating the inhalation dose of metals remains underexplored. A comprehensive understanding of these determinants is essential to assess the health risks associated with inhaling e-cig aerosols, which may contain potentially harmful metals.
Objectives: The aim of this study is to elucidate the mass and inhalation doses of potentially harmful metals in e-cig aerosols by different particle size and their association with the various atomising powers of e-cig devices and flavours.
Effects of E-Cigs on Physiological Pathways and Proposed Therapeutic Intervention with Bixin.
Biomedicines
November 2024
Department of Pharmaceutical Sciences, USF Health Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
Electronic cigarettes (e-cigs) have increased in popularity and usage over the last few decades. There is rising concern regarding the long-term effects of e-cigs on human health, considering their relatively recent introduction to the market. E-cigs are generally composed of a liquid containing nicotine and various chemicals, a battery, a vaporization chamber, and a coil that serves to heat the liquid upon inhalation of the mouthpiece.
View Article and Find Full Text PDFUnveiling per- and polyfluoroalkyl substances contamination in e-cigarette refill liquids: A comprehensive analytical assessment.
Sci Total Environ
January 2025
Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology (GUT), ul. G. Narutowicza 11/12, 80-233 Gdańsk, Poland; EcoTech Center, Gdańsk University of Technology (GUT), ul. G. Narutowicza 11/12, 80-233 Gdańsk, Poland.
A robust analytical method was developed for the determination of per- and polyfluoroalkyl substances (PFAS) in e-cigarette refill liquids using solid-phase extraction (SPE) with weak anion-exchange sorbent, followed by detection with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The design of experiment approach was employed to optimize sample preparation, leading to the validation of the method with limits of detection for PFAS ranging from 0.24 to 1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!