Synthesis and Utility of Dihydropyridine Boronic Esters.

Angew Chem Int Ed Engl

Department of Biochemistry, Division of Chemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-0938, USA.

Published: February 2016

When activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester. This intermediate allows access to a number of valuable substituted pyridine, dihydropyridine, and piperidine products.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769604PMC
http://dx.doi.org/10.1002/anie.201510027DOI Listing

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