This is a case report with serial imaging showing progression of diffuse osteonecrosis in a patient after a diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH). While bone marrow involvement in HLH has been long noted at histological evaluation and is itself one of the diagnosis criteria, to the best of our knowledge, there has been no previous publication addressing osseous image findings in a patient with HLH.
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http://dx.doi.org/10.1155/2015/730719 | DOI Listing |
J Assoc Physicians India
October 2024
Senior Resident, Department of Diagnostic and Intervention Radiology, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India.
Am J Nucl Med Mol Imaging
August 2024
Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata Niigata, Japan.
The purpose of this study is to investigate bone SPECT/CT and diffusion-weighted MR imaging (DWI) in medication-related osteonecrosis of the jaw (MRONJ), focusing on the correlation between standardized uptake values (SUVs) and apparent diffusion coefficient (ADC) values. Twenty-nine patients with MRONJ who underwent SPECT/CT and DWI were included in this study. SUVs (maximum and mean) with SPECT/CT, and ADC values (maximum, mean and minimum) with DWI were analyzed on characteristics in MRONJ, such as stage, location, medication and underlying disease, by Mann-Whitney U test.
View Article and Find Full Text PDFJ Clin Pathol
January 2025
Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA
J Maxillofac Oral Surg
August 2024
Department of Oral and Maxillofacial Surgery, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand 249203 India.
Extranodal non-Hodgkin's lymphoma (NHL) afflicting the head and neck region is rare, accounting for only about 5%. Diffuse large B-cell lymphoma (DLBCL) is the most common type of NHL affecting the oral cavity. Due to its variable clinical presentation and non-pathognomic course, it can be easily misdiagnosed with overlapping characteristics to common oral pathologies.
View Article and Find Full Text PDFMol Imaging Radionucl Ther
June 2024
Tuen Mun Hospital, Department of Radiology and Nuclear Medicine, Nuclear Medicine Unit, Hong Kong, China.
A 52-year-old female patient with metastatic breast cancer receiving denosumab for 7 years presented with marked diffuse tracer uptake in the mandible on Tc-99m-methylene diphosphonate bone scintigraphy, resembling the Lincoln sign. A diagnosis of medication-related osteonecrosis of the jaw (MRONJ) was confirmed, leading to immediate discontinuation of denosumab. Conservative therapy, including limited debridement and oral rinses, was initiated.
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