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| http://dx.doi.org/10.1530/ERP-14-0072 | DOI Listing |
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AI integrations with lung cancer screening: Considerations in developing AI in a public health setting.
Eur J Cancer
March 2025
Mount Sinai Health System, New York, NY, USA. Electronic address:
Lung cancer screening implementation has led to expanded imaging of the chest in older, tobacco-exposed populations. Growing numbers of screening cases are also found to have CT-detectable emphysema or elevated levels of coronary calcium, indicating the presence of coronary artery disease. Early interventions based on these additional findings, especially with coronary calcium, are emerging and follow established protocols.
View Article and Find Full Text PDFProtective functions of liver X receptor α on calcified aortic valve: involvement of regulating endoplasmic reticulum-mediated osteogenic differentiation.
Cardiovasc Res
March 2025
Cardiovascular Department, The First Affiliated Hospital, Fujian Medical University; Key Laboratory of Metabolic Heart Disease in Fujian Province; Clinical Research Centre of Metabolic Cardiovascular Disease in Fujian Province，Fuzhou  350005, China.
Aims: Effective therapeutic drugs for calcific aortic valve disease (CAVD) are lacking, although its incidence has been increasing over the past decade, and is predicted to continue rising in the future. This study aimed to explore the role and potential mechanisms of liver X receptor α (LXRα) in CAVD, which offers a promising approach for treating CAVD.
Methods And Results: Osteogenic stimulation was performed following which a substantial downregulation of LXRα was observed in human calcific aortic valves and in valvular interstitial cells.
Thrombospondin-1 binds to integrin β3 to inhibit vascular calcification through suppression of NF-κB pathway.
J Pathol
March 2025
Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation; Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Guangzhou, PR China.
Vascular calcification is an important risk factor related to all-cause mortality of cardiovascular events in patients with chronic kidney disease (CKD). Vascular extracellular matrix (ECM) proteins have been demonstrated to regulate vascular calcification. ECM protein thrombospondin 1 (THBS1/TSP-1) plays a critical role in the regulation of vascular diseases.
View Article and Find Full Text PDFTranslocated anterior mitral leaflet sparing is a viable treatment option for both degenerative and functional mitral valve disease.
J Thorac Dis
February 2025
Department of Cardiac Surgery, Centre Cardiologique du Nord, Saint-Denis, France.
Background: We present a technique for mitral valve (MV) replacement that preserves the anterior mitral leaflet (AML) using complete chordal-sparing mitral valve replacement (CCS-MVR), which maintains the architecture of the left ventricle. This technique is beneficial for patients with functional, degenerative, and infective MV disease who were unable to undergo MV repair. The objective of this study is to ascertain the most efficacious treatment for MV disease.
View Article and Find Full Text PDFOlezarsen in Patients with Hypertriglyceridemia at High Cardiovascular Risk: Rationale and Design of the Essence-TIMI 73b Trial.
Am Heart J
March 2025
TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
Background: Elevated triglycerides are an important risk factor for atherosclerosis. However, the magnitude of triglyceride lowering with currently available therapies is modest and the impact of triglyceride-lowering on atherosclerosis remains undefined. Olezarsen is an antisense oligonucleotide (ASO) targeting mRNA for apolipoprotein C-III (apoC-III), an inhibitor of triglyceride clearance.
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