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| http://dx.doi.org/10.1530/ERP-15-0009 | DOI Listing |
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Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re-PHIRE.
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Department of Cardiology, Pulmonology, and Intensive Care Medicine, Center for Molecular Medicine Cologne (CMMC), Cologne Cardiovascular Research Center (CCRC), Medical Faculty, University of Cologne, Cologne, Germany.
Aims: Despite receiving guideline-directed medical heart failure (HF) therapy, patients with pulmonary hypertension associated with left heart disease (PH-LHD) experience higher mortality and hospitalization rates than the general HF population. AZD3427 is a functionally selective, long-acting mimetic of relaxin, a hormone that has the potential to induce vasodilation and prevent fibrosis. In a phase 1b study conducted in patients with HF, AZD3427 demonstrated a favourable safety and pharmacokinetic profile.
View Article and Find Full Text PDFSerial changes of systemic ventricular function and atrioventricular valve function in patients with failing Fontan.
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Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, University Hospital of Technische Universität München, Munich Germany, Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universität München, Munich, Germany, Europäisches Kinderherzzentrum München, Munich, Germany.
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View Article and Find Full Text PDFPeriaortic fat thickness and cardiovascular risk factors in children with congenital adrenal hyperplasia.
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Department of Pediatric Endocrinology, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
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