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FTDMP: A Framework for Protein-Protein, Protein-DNA, and Protein-RNA Docking and Scoring.
Proteins
January 2025
Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
FTDMP is a software framework for biomolecular docking and scoring. It can perform docking of subunits containing one or more protein, DNA, or RNA chains, followed by subsequent scoring of the resulting models. FTDMP can also be used for the ranking of user-provided models of biomolecular complexes, generated by any structure prediction method.
View Article and Find Full Text PDFCare pathways for individuals with post-anoxic disorder of consciousness (CaPIADoC): an inter-society Consensus Conference.
Neurol Sci
November 2024
IRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Di Scandicci 269, 80143, Florence, Italy.
Background: Accurate recognition of consciousness level and detection of neurological complications since the intensive care unit are crucial for an appropriate prognostication and tailored treatment in patients with post-anoxic disorder of consciousness (DoC).
Objective: The present inter-society Consensus Conference aimed at addressing current debates on diagnostic and prognostic procedures.
Methods: Twelve working groups involving 22 multidisciplinary professionals (membership of 9 Scientific Societies and 2 patients' family Associations) conducted a systematic literature review focused on 12 questions addressing diagnosis (n = 5) and prognosis (n = 7).
275th ENMC international workshop: Seronegative myasthenia gravis: An update paradigm for diagnosis and management, 9-11 February 2024, Hoofddorp, the Netherlands.
Neuromuscul Disord
November 2024
Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Instituto Neurologico Carlo Besta, Milano, Italy. Electronic address:
The 275th ENMC workshop on the diagnosis and management of seronegative myasthenia gravis (SNMG) was held on February 9-11, 2024. The participants included experts in the field of adult and pediatric MG together with patient representatives. This workshop aimed to redefine SNMG in view of recent diagnostic and therapeutic updates and to identify patient unmet needs.
View Article and Find Full Text PDFOxygen therapy in acute hypoxemic respiratory failure: guidelines from the SRLF-SFMU consensus conference.
Ann Intensive Care
September 2024
Service de Médecine Intensive - Réanimation, AP-HM, Hôpital Nord, Marseille, France.
Introduction: Although largely used, the place of oxygen therapy and its devices in patients with acute hypoxemic respiratory failure (ARF) deserves to be clarified. The French Intensive Care Society (Société de Réanimation de Langue Française, SRLF) and the French Emergency Medicine Society (Société Française de Médecine d'Urgence, SFMU) organized a consensus conference on oxygen therapy in ARF (excluding acute cardiogenic pulmonary oedema and hypercapnic exacerbation of chronic obstructive diseases) in December 2023.
Methods: A committee without any conflict of interest (CoI) with the subject defined 7 generic questions and drew up a list of sub questions according to the population, intervention, comparison and outcomes (PICO) model.
Recommendations on Robotic Hepato-Pancreato-Biliary Surgery. The Paris Jury-Based Consensus Conference.
Ann Surg
January 2025
Department of Surgery and Transplantation, University of Zurich, Zurich, Switzerland.
Article Synopsis
- The objective was to create the first consensus guidelines for the safety and use of robotics in Hepato-Pancreatic-Biliary (HPB) surgery, while also identifying areas for future research.
- A multidisciplinary jury, using the Zurich-Danish model, formulated recommendations based on expert panels' responses to key questions and the best available evidence from 285 studies.
- The results highlighted the feasibility and value of robotic surgery in HPB operations but stressed the need for proper expertise and training, as well as prospective registries for evaluating outcomes in future trials.*
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