We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889808 | PMC |
| http://dx.doi.org/10.1038/nn.4199 | DOI Listing |
Publication Analysis
Top Keywords
indirect pathway
8
nucleus accumbens
8
neuropathic pain
8
pathway nucleus
4
accumbens shell
4
shell amplifies
4
amplifies neuropathic
4
pain examined
4
examined adaptations
4
adaptations nucleus
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!