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Treatment Outcomes of Tyrosine Kinase Inhibitors and Durvalumab Plus Tremelimumab After Atezolizumab Plus Bevacizumab for Hepatocellular Carcinoma.
Anticancer Res
January 2025
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Background/aim: Atezolizumab plus bevacizumab (AteBev) is widely used as a first-line treatment for advanced hepatocellular carcinoma (HCC). However, evidence regarding the optimal drug sequence following AteBev treatment is limited. This study aimed to compare the treatment outcomes between tyrosine kinase inhibitors (TKIs) and durvalumab plus tremelimumab (DurTre) following AteBev treatment.
View Article and Find Full Text PDFN Protein of Tomato Spotted Wilt Virus Proven to Be Antagonistic Against Tomato Yellow Leaf Curl Virus in Nicotiana benthamiana.
Mol Plant Pathol
January 2025
Facility Horticultural Laboratory of Universities in Shandong, Weifang University of Science and Technology, Shouguang, Shandong, China.
Two phylogenetically unrelated viruses transmitted by different insect vectors, tomato spotted wilt virus (TSWV) and tomato yellow leaf curl virus (TYLCV), are major threats to tomato and other vegetable production. Although co-infections of TSWV and TYLCV on the same host plant have been reported on numerous occasions, there is still lack of research attempting to elucidate the mechanisms underlying the relationship between two viruses when they coexist in the same tomato or other plants. After assessing the effect of four TSWV-coded proteins on suppressing TYLCV in TSWV N transgenic Nicotiana benthamiana seedlings, the TSWV N protein proved to be effective in reducing TYLCV quantity and viral symptoms.
View Article and Find Full Text PDFOnline control ability affects precision fitting performances of long-term Tai Chi practitioners in older adults.
Gait Posture
December 2024
Department of Health Science and Kinesiology, Georgia Southern University, Statesboro, USA. Electronic address:
Background: Age-related decline in goal-directed behavior could be risky for older adults to maintain daily activities. Our previous studies have shown that long-term Tai Chi (TC) practice could improve motor performance and postural control during goal-directed tasks. However, there was a paucity of studies examining TC's effects on online control of goal-directed action.
View Article and Find Full Text PDFSilent threats of lead-based paints in toys and households to children's health and development.
J Hazard Mater
December 2024
Consortium on Health, Environment, Education, and Research (CHEER), The Education University of Hong Kong, Tai Po, Hong Kong. Electronic address:
Lead (Pb), a highly toxic heavy metal, poses a significant global health risk, particularly to children. Widely used in paint manufacturing for its remarkable corrosion-resistance properties Pb exposure has been linked to severe health issues, including reduced neurotransmitter levels, organ damage, potentially leading to death in extreme cases. Children Are particularly vulnerable, with Pb toxicity primarily affecting the brain, reproductive, kidneys, and cardiovascular systems.
View Article and Find Full Text PDFA study of specific immunoglobulin G4 expression in allergic rhinitis and its value in assessing efficacy and in predicting prognosis of sublingual immunotherapy.
Kaohsiung J Med Sci
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian Province, China.
Allergic rhinitis (AR) is a widespread health issue with a rising global prevalence, and sublingual immunotherapy (SLIT) has shown efficacy in AR treatment. We examined specific immunoglobulin G4 (sIgG4) expression in AR and its role in evaluating SLIT efficacy and predicting patient prognosis. We compared total nasal symptom score (TNSS), total medication score (TMS), visual analogue scale (VAS) score, inflammatory cytokines, and immune function markers in AR patients before and after SLIT.
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