Acoustically triggered microcannons, capable of loading and firing nanobullets (Nbs), are presented as powerful microballistic tools. Hollow conically shaped microcannon structures have been synthesized electrochemically and fully loaded with nanobullets made of silica or fluorescent microspheres, and perfluorocarbon emulsions, embedded in a gel matrix stabilizer. Application of a focused ultrasound pulse leads to the spontaneous vaporization of the perfluorocarbon emulsions within the microcannon and results in the rapid ejection of the nanobullets. Such Nbs "firing" at remarkably high speeds (on the magnitude of meters per second) has been modeled theoretically and demonstrated experimentally. Arrays of microcannons anchored in a template membrane were used to demonstrate the efficient Nbs loading and the high penetration capabilities of the ejected Nbs in a tissue phantom gel. This acoustic-microcannon approach could be translated into advanced microscale ballistic tools, capable of efficient loading and firing of multiple cargoes, and offer improved accessibility to target locations and enhanced tissue penetration properties.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsnano.5b07080 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Quantitative Analysis of Internal and External Loads in Aviation Firefighting Using a Simulated Scenario.
Healthcare (Basel)
January 2025
Biomechanics, Physical Performance, and Exercise Research Group, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2000, Australia.
Background/objectives: Aviation firefighting is a strenuous occupation that requires individuals to engage in intense physical activity amidst elevated stress levels and extreme environmental conditions. Despite this, there has been limited investigation regarding the internal and external loads associated with aviation firefighting tasks, which include hose dragging, stair climbing, casualty evacuation, and fire extinguishing in airports and aircrafts. The aim of this study was to examine the internal and external loads placed on aviation firefighters.
View Article and Find Full Text PDFSir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy.
Elife
January 2025
Translational Science and Therapeutics Division, Human Biology Division, Fred Hutchinson Cancer Center, Seattle, United States.
The association between late replication timing and low transcription rates in eukaryotic heterochromatin is well known, yet the specific mechanisms underlying this link remain uncertain. In , the histone deacetylase Sir2 is required for both transcriptional silencing and late replication at the repetitive ribosomal DNA (rDNA) arrays. We have previously reported that in the absence of , a de-repressed RNA PolII repositions MCM replicative helicases from their loading site at the ribosomal origin, where they abut well-positioned, high-occupancy nucleosomes, to an adjacent region with lower nucleosome occupancy.
View Article and Find Full Text PDFOptimizing hydrophilic drug incorporation into SEDDS using dry reverse micelles: a comparative study of preparation methods.
Drug Deliv Transl Res
January 2025
Thiomatrix Forschungs- und Beratungs GmbH, Trientlgasse 65, 6020, Innsbruck, Austria.
Aim: It was the aim of this study to compare two different dry reverse micelle (RM) preparation methods for the incorporation of hydrophilic drugs into oral self-emulsifying drug delivery systems (SEDDS).
Methods: Cationic ethacridine lactate, anionic fluorescein sodium salt and the antibiotic peptide bacitracin were solubilized in RM containing sodium docusate, soy phosphatidylcholine and sorbitan monooleate in highly lipophilic oils such as squalane. In the dry addition (DA) method, drugs were directly added to empty RM in their powder form.
Light-driven in-situ synthesis of nano-sulfur and graphene oxide composites for efficient removal of heavy metal ions.
J Hazard Mater
January 2025
State Key Lab of Geohazard prevention & Geoenvironment protection, College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. Electronic address:
Sulfur nanoparticles (SNPs) and their composites are promising for heavy metal adsorption, yet current SNPs often lack surface S, leading to low affinity toward heavy metal and ease of aggregation. Here, we report a simple light-driven method for facile prepare SNPs with surfaces enriched with S and in-situ load them onto graphene oxide (GO) to fabricate GO-S composites. Under illumination, the O generated by photosensitizer phloxine B was able to oxidize S into elemental SNPs.
View Article and Find Full Text PDFTechnical note: A silenced hybrid 3D-printed self-loading pistol of the YEET family.
Forensic Sci Int
January 2025
Ballistics laboratory, National Institute for Criminalistics and Criminology, Vilvoordsesteenweg 98, Brussels 1120, Belgium. Electronic address:
Since the release of the first 3D-printed firearm, "The Liberator," the occurrence of 3D-printed firearms in criminal activities has increased, highlighting the need for forensic research on these weapons. This study presents a technical examination of a 3D-printed firearm received by the National Institute of Criminalistics and Criminology (NICC), focusing on its design, ballistic performance, and its potential for microscopic comparative analysis. The firearm, resembling a 3D-printed pistol Yeet22, is primarily constructed from polymer parts, with the exception of the firing pin, barrel, and various springs and screws.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!