A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma. | LitMetric

Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma.

Neuro Oncol

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York (M.I.d., S.B., A.T., A.A.O., C.P.N., E.P., T.J.K., L.M.D., I.K.M.); Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York (R.J.Y., J.R., J.T., J.A.-P., A.I.H., S.B.T.); Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (M.R.); Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, New York (J.R.C.); Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York (C.C., I.K.M.); Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York (P.H.G.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York (J.H.O., S.B.T.); Agios Pharmaceuticals, Cambridge, Massachusetts (K.S., D.Z., K.Y.); Department of Neurology, Evelyn F. McKnight Brain Institute, University of Miami, Miami, Florida (C.D.); Advanced Imaging Research Center, University Of Texas Southwestern Medical Center, Dallas, Texas (E.M., C.C.); GE Healthcare, Berlin, Germany (R.N.); Department of Pharmacology, Weill-Cornell Graduate School of Biomedical Sciences, New York, New York (I.K.M.).

Published: February 2016

AI Article Synopsis

  • Most gliomas (grades II and III) have a mutation in the IDH gene, leading to the accumulation of R-2-hydroxyglutarate (2HG), detectable via magnetic resonance spectroscopy (MRS).
  • A study introduced a new MR imaging protocol for 2HG-MRS in 89 glioma patients, revealing that tumor size affects the ability to detect 2HG, with higher sensitivity in larger tumors.
  • The findings suggest that 2HG levels correlate with tumor characteristics and can decrease with effective therapy, potentially serving as a noninvasive biomarker for monitoring IDH-mutant glioma treatments.

Article Abstract

Background: The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) and accumulate the metabolite R-2-hydroxyglutarate (R-2HG). Prior studies showed that this metabolite can be detected in vivo using proton magnetic-resonance spectroscopy (MRS), but the sensitivity of this methodology and its clinical implications are unknown.

Methods: We developed an MR imaging protocol to integrate 2HG-MRS into routine clinical glioma imaging and examined its performance in 89 consecutive glioma patients.

Results: Detection of 2-hydroxyglutarate (2HG) in IDH-mutant gliomas was closely linked to tumor volume, with sensitivity ranging from 8% for small tumors (<3.4 mL) to 91% for larger tumors (>8 mL). In patients undergoing 2HG-MRS prior to surgery, tumor levels of 2HG corresponded with tumor cellularity but not with tumor grade or mitotic index. Cytoreductive therapy resulted in a gradual decrease in 2HG levels with kinetics that closely mirrored changes in tumor volume.

Conclusions: Our study demonstrates that 2HG-MRS can be linked with routine MR imaging to provide quantitative measurements of 2HG in glioma and may be useful as an imaging biomarker to monitor the abundance of IDH-mutant tumor cells noninvasively during glioma therapy and disease monitoring.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724186PMC
http://dx.doi.org/10.1093/neuonc/nov307DOI Listing

Publication Analysis

Top Keywords

disease monitoring
8
glioma imaging
8
tumor
6
glioma
5
integration 2-hydroxyglutarate-proton
4
2-hydroxyglutarate-proton magnetic
4
magnetic resonance
4
resonance spectroscopy
4
spectroscopy clinical
4
clinical practice
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: