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Curvature Memory in Electrically Stimulated Lipid Membranes.
Langmuir
January 2025
Department of Physics and Astronomy, University of Tennessee, Knoxville, Tennessee 37996, United States.
We demonstrate, using non-equilibrium molecular dynamics simulations, that lipid membrane capacitance varies with surface charge accumulation linked to membrane shape and curvature changes. Specifically, we show that lipid membranes exhibit a hysteretic response when exposed to oscillatory electric fields. The electromechanical coupling in these membranes leads to hysteretic buckling, in which the membrane can spontaneously buckle in one of two distinct directions along the electric field, even for the same ionic charge accumulation at the water-membrane interface.
View Article and Find Full Text PDFLarge and Stable Nanopores Formed by Complement Component 9 for Characterizing Single Folded Proteins.
ACS Nano
January 2025
Adolphe Merkle Institute, University of Fribourg, Fribourg 1700, Switzerland.
Biological nanopores offer a promising approach for single-molecule analysis of nucleic acids, peptides, and proteins. The work presented here introduces a biological nanopore formed by the self-assembly of complement component 9 (C9). This exceptionally large and cylindrical protein pore is composed of 20 ± 4 monomers of C9 resulting in a diameter of 10 ± 4 nm and an effective pore length of 13 nm.
View Article and Find Full Text PDFNanocrystalline formulations typically contain stabilizing additives to minimize the risk of particle growth or agglomeration. This risk is particularly relevant when the nanosuspension is converted into a solid drug product as the original state of the nanosuspension should be restored upon redispersion of the drug product in vivo. In this work, the behavior of different nonionic and anionic surfactants in solid nanocrystalline formulations and their effects on redispersibility under biorelevant conditions were investigated.
View Article and Find Full Text PDFA novel method for expressing and purifying large quantities of functional and stable human voltage-gated proton channel (hH1).
Protein Sci
February 2025
Cell Physiology and Molecular Biophysics Department, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Purifying membrane proteins has been the limiting step for studying their structure and function. The challenges of the process include the low expression levels in heterologous systems and the requirement for their biochemical stabilization in solution. The human voltage-gated proton channel (hH1) is a good example of that: the published protocols to express and purify hH1 produce low protein quantities at high costs, which is an issue for systematically characterizing its structure and function.
View Article and Find Full Text PDFRemoval of ciprofloxacin using polymeric nanocomposites synthesized from alkylated chitosan ionic macromonomers, ionic monomers and hydrotalcite.
Int J Biol Macromol
January 2025
Polymers Department, Faculty of Chemical Sciences, University of Concepción, Box 160-C, Concepción 4070371, Chile. Electronic address:
The contamination of water systems by antibiotics such as ciprofloxacin (CIP), which is used to treat bacterial infections, poses severe risks to environmental safety and public health. To address this issue, a novel zwitterionic polymeric nanocomposite (PNs-HTC) was developed in this study. This novel material was synthesized using alkylated chitosan ionic macromonomers, ionic monomers and combined with hydrotalcite (HTC) via in situ free radical polymerization.
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