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Exploring the Therapeutic Landscape: A Narrative Review on Topical and Oral Phosphodiesterase-4 Inhibitors in Dermatology.
Pharmaceutics
January 2025
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Phosphodiesterase-4 (PDE4) is involved in the synthesis of inflammatory cytokines that mediate several chronic inflammatory disorders, including psoriasis and atopic dermatitis. In recent years, the therapeutic armamentarium in dermatology has expanded with the introduction of PDE4 inhibitors, both in oral and topical formulations. PDE4 inhibitors have gained increasing interest due to their remarkable safety record and ease of prescription, as evidenced by the recent influx of literature detailing its off-label uses.
View Article and Find Full Text PDFIn Vivo Characterization of the Inflammatory Infiltrate in Discoid Lupus Erythematosus (DLE) by Line-Field Confocal Optical Coherence Tomography (LC-OCT).
Dermatol Pract Concept
January 2025
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania, Naples, Italy.
Introduction: Previous studies have investigated the density of dermal papillae (DP) in normal skin using reflectance confocal microscopy (RCM), a non-invasive imaging technique that allows a real time, high-resolution imaging of the skin, although no histological confirmation was provided. The aim of the present study was to compare the RCM evaluation of DP density in healthy skin with horizontal histopathological sections (HHS), a technique that provides a horizontal view of the skin.
Methods: Ten adult patients were selected, and a healthy skin area was marked for RCM examination and a subsequent 5-mm punch biopsy that was processed for HHS.
Solitary verrucous plaque on the chin: hypertrophic discoid lupus erythematosus.
An Bras Dermatol
January 2025
Department of Pathology, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Epidemiology of discoid lupus erythematosus among adults in the United States: a cross-sectional analysis.
Int J Dermatol
January 2025
Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
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