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Purpose: The aim of this study was to evaluate the efficacy and safety of 177Lu-DOTA-IBA for pain palliation in participants with bone metastases and confirm its potential for treating bone metastasis.
Patients And Methods: Overall, 69 participants with bone metastases were included. 68Ga-DOTA-IBA PET/CT was performed within 1 week before treatment.
Development and testing of a generic patient decision aid for end-of-life care.
Patient Educ Couns
March 2025
Center for Shared Decision-making, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
Objectives: The objective of this study was to develop and test a patient decision aid for end-of-life care to be used when some or all life-sustaining treatments have been withheld or withdrawn.
Methods: A multi-professional, multi-sectorial group together with patients and relatives used a systematic process to develop and test the patient decision aid, including alpha and beta testing.
Results: Healthcare professionals, patients and relatives were involved in the development and testing.
The Role of Radiation Therapy for Palliation of Hematologic Malignancies.
Semin Radiat Oncol
January 2025
Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO.. Electronic address:
Palliative RT is an effective tool in management and treatment of patients with hematologic malignancies. Even relatively low doses of palliative RT can quickly and effectively relieve pain and other symptoms impairing quality of life and function. As so many diseases are represented by the umbrella term, "hematologic malignancies," and each disease has its own natural history and prognosis, the indications for palliative RT are heterogeneous.
View Article and Find Full Text PDFSafety Analysis of Co-Administration of Radiation Therapy with Enfortumab Vedotin Based Regimens in Metastatic Urothelial Carcinoma.
Clin Genitourin Cancer
December 2024
Department of Urology, University of California Irvine Medical Center, Orange, CA.
Article Synopsis
- Enfortumab vedotin (EV) and pembrolizumab (P) are standard treatments for advanced urothelial carcinoma, and this study investigates the safety of combining EV with radiation therapy (RT).
- The study involved nine patients who received EV and RT simultaneously, focusing on the side effects of radiation and symptom relief.
- Results showed that adverse effects were mostly mild, with significant symptom relief achieved; further research is suggested for broader conclusions.
Surgical Management of Gynecologic Cancers.
Hematol Oncol Clin North Am
February 2025
Department of Obstetrics and Gynecology, University of California, 333 City Boulevard West, Suite 1400, Orange, CA 92868, USA.
This article addresses the role of surgery in the management of gynecologic cancers with liver metastases. The authors review the short-term and long-term outcomes of aggressive resection through retrospective and randomized studies. Although the data supporting aggressive resection of liver metastasis are largely retrospective and case based, the randomized control data to address neoadjuvant versus chemotherapy have been widely criticized.
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