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Oxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization.
Nat Commun
December 2024
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
Sand and dust storms (SDS) can cause adverse health effects, with the oxidative potential (OP) and environmentally persistent free radicals (EPFRs) inducing oxidative stress. We mapped the OP and EPFRs concentrations at 1735 sites in China during SDS periods using experimental data for 2021-2023 and a random forest model. We examined 855,869 hospitalizations during SDS events for 2015-2022 in Beijing, China.
View Article and Find Full Text PDFA Mechanistic Approach to Optimize Combination Antibiotic Therapy.
Biosystems
December 2024
Department of Pharmacy, UiT - The Arctic University of Norway, Tromsø, Norway; Department of Biology, Pennsylvania State University, University Park, PA, U.S.A; Department of Digital Health Sciences and Biomedicine, University of Siegen, Siegen, Germany; Bioinformatics and Modelling, Norwegian Institute of Public Health, Oslo, Norway. Electronic address:
Antimicrobial resistance is one of the most significant healthcare challenges of our times. Multidrug or combination therapies are sometimes required to treat severe infections; for example, the current protocols to treat pulmonary tuberculosis combine several antibiotics. However, combination therapy is usually based on lengthy empirical trials, and it is difficult to predict its efficacy.
View Article and Find Full Text PDFEstimating the effect of annual PM exposure on mortality in India: a difference-in-differences approach.
Lancet Planet Health
December 2024
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cardiology, Danderyd University Hospital, Danderyd, Sweden.
Background: In 2019, the Global Burden of Diseases, Injuries, and Risk Factors Study attributed 0·98 million deaths to ambient air pollution in India based on potentially inappropriate exposure-response functions from countries with low air pollution levels. Instead, using data from India, we investigated long-term exposure to PM and all-cause mortality with a causal inference method.
Methods: We collected national counts of annual mortality from 2009 to 2019 from the Civil Registration System at the district level to calculate annual district-level mortality rate as our main outcome and obtained annual PM concentrations from a high-resolution spatiotemporal model.
Association Between Multimorbidity and Depression in Older Adults: Evidence From Six Large Longitudinal Cohorts.
Am J Geriatr Psychiatry
November 2024
West China School of Public Health and West China Fourth Hospital, Sichuan University, Sichuan, Chengdu, China. Electronic address:
Background: Multimorbidity may increase the risk of depression in older adults, but the global average effect of multimorbidity on depression remains unknown. This research aimed to exclude the regional heterogeneity to quantify the exposure-response association between multimorbidity and depression in older adults worldwide.
Method: We collected 23,947 participants aged 65 years or above from six large prospective cohorts from developed and developing countries, including Mexico, South Korea, Europe, America, China, and England.
Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Few studies have investigated the effects of mixed polycyclic aromatic hydrocarbon (PAH) exposure on CVD prevalence. We aimed to evaluate the association between mixed PAHs exposure and CVD and determine the extent to which these links are mediated by inflammatory indices.
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