AI Article Synopsis
- The Msh4-Msh5 and Mlh1-Mlh3 complexes are crucial for repairing double-strand breaks during meiosis, working alongside Exo1 and Sgs1-Top3-Rmi1 to create crossovers from double Holliday junctions.
- This review highlights that the functions of Msh4-Msh5 and Mlh1-Mlh3 in meiosis differ from their roles in post-replicative mismatch repair (MMR).
- The article also presents models explaining how these complexes facilitate meiotic crossover formation, essential for the proper segregation of chromosomes during the first division of meiosis.
Article Abstract
The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the asymmetric cleavage of double Holliday junctions (dHJ) to form crossovers. This review discusses how meiotic roles for Msh4-Msh5 and Mlh1-Mlh3 do not fit paradigms established for post-replicative MMR. We also outline models used to explain how these factors promote the formation of meiotic crossovers required for the accurate segregation of chromosome homologs during the Meiosis I division.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740264 | PMC |
| http://dx.doi.org/10.1016/j.dnarep.2015.11.024 | DOI Listing |
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