Background: Gastric and colonic alpha-synuclein immunoreactivity has been reported in patients with Parkinson's disease (PD). However, enteric alpha-synuclein also has been reported in healthy individuals.
Objectives: We aimed to investigate the utility of alpha-synuclein immunoreactivity from gastric and colonic mucosal tissues obtained by routine endoscopy to detect PD, and to correlate the pathological burden of alpha-synuclein with motor and nonmotor features of PD.
Methods: We recruited 104 study subjects, consisting of 38 patients with PD, 13 patients with probable multiple system atrophy (MSA), and 53 healthy controls. Gastric and colonic mucosal tissues obtained by endoscopic gastroduodenoscopy and colonoscopy were assessed using alpha-synuclein immunohistochemistry. Detailed motor and nonmotor features of PD were correlated with enteric alpha-synuclein immunoreactivity.
Results: No difference was seen in the enteric α-SYN immunoreactivity among patients with PD (31.6% for stomach and 10.4% for colon), patients with MSA (40.0% for stomach and 8.0% for colon), and healthy controls (33.3% for stomach and 18.5% for colon). The frequency of positive alpha-synuclein immunoreactivity was higher in gastric biopsy tissues than in colonic biopsy tissues in all of the study groups (P < 0.05). No significant correlation was found between the presence of alpha-synuclein immunoreactivity and the motor and nonmotor features of PD.
Conclusions: The presence of alpha-synuclein immunoreactivity in gastric and colonic mucosa was detected in a similar manner in patients with PD, patients with MSA, and controls, thus suggesting a limited role of enteric mucosal alpha-synuclein as a diagnostic biomarker for PD. Future studies are warranted to detect pathological alpha-synuclein strains.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mds.26473 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extra-Cavitary Primary Effusion Lymphoma in a Patient Co-infected With HIV-1 and HIV-2: A Case Review.
Cureus
December 2024
Infectious Diseases, Hospital Garcia de Orta, Lisbon, PRT.
Extra-cavitary primary effusion lymphoma (PEL), often associated with human herpes virus 8 (HHV8) infection, represents a rare and aggressive form of non-Hodgkin lymphoma, which is predominantly found in individuals with severe immunosuppression. As an acquired immunodeficiency syndrome (AIDS)-associated lymphoma, PEL typically manifests in the context of advanced human immunodeficiency virus (HIV) infection, requiring tailored therapeutic approaches to manage both the lymphoma and underlying immunodeficiency. A 53-year-old male patient from Cape Verde presented with a three-day history of fever, night sweats, right iliac fossa pain, hematochezia, and an unintentional weight loss of five kilograms over the previous two months.
View Article and Find Full Text PDFAcute Gastric Necrosis Secondary to Mesenteric Ischemia: A Case Report and Literature Review.
Cureus
December 2024
General Surgery, Hospital Regional de Alta Especialidad Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado B Veracruz, Veracruz, MEX.
Acute gastric dilation and necrosis, although rare, are most commonly associated with eating disorders. We present a case of a patient with a history of prior fundoplication and complete intestinal obstruction, which led to severe gastric dilation and subsequent gastric necrosis. The condition was successfully managed through partial gastrectomy.
View Article and Find Full Text PDFLaparoscopic surgery is associated with increased risk of postoperative peritoneal metastases in T4 colon cancer: a propensity score analysis.
Int J Colorectal Dis
January 2025
Department of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Background: This study aims to evaluate the postoperative safety, long-term survival, and postoperative peritoneal metastases (PPM) rate associated with laparoscopic surgery (LS) for T4 colon cancer.
Materials And Methods: After propensity score matching, there were 68 patients in each of the LS and Open surgery groups. The primary outcomes were the 3-year OS, DFS, and PPM rates.
Two Cases of Colonic Perforation Following Upper Gastrointestinal Barium Examinations.
Cureus
December 2024
Department of Surgery, Kitakyushu City Yahata Hospital, Kitakyushu, JPN.
Article Synopsis
- The report discusses two cases of colonic perforation that happened after an upper gastrointestinal series (UGIS) using barium, highlighting both its benefits for detecting gastric issues and its rare but serious risks.
- It outlines the mechanisms behind perforation, identifies risk factors, and reviews imaging diagnosis challenges along with treatment options like Hartmann's procedure or colostomy, underscoring the importance of prompt diagnosis and surgical action.
- The findings suggest that while UGIS is generally safe, awareness of its potential dangers is crucial, and advancements in endoscopic techniques may lead to a shift towards endoscopy as a preferred screening method in the future.
Gastric Stenosis Four Years After Adjustable Gastric Band Removal Surgery-A Video Case Report.
Obes Surg
December 2024
Division of Gastroenterology, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
Laparoscopic adjustable gastric banding (LAGB) is a type of bariatric surgery. Gastric stenosis or obstruction is a known complication of LAGB; however, its occurrence after band removal is extremely rare. A 60-year-old female, who had undergone LAGB 6 years earlier and band removal 4 years prior, presented to the hospital with recurrent vomiting.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!