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Introduction: The complexity of healthcare is dynamic and requires educators to evaluate how to prepare pediatric nurse practitioners (PNPs). The research team sought to evaluate procedures currently being performed by primary and acute care PNPs in clinical practice and determine how this aligns with the educational preparation recommended for certification.
Method: A cross-sectional survey of primary and acute care PNPs were evaluated through an online survey.
The Known and Unknown of Global Tick-Borne Viruses.
Viruses
November 2024
Key Laboratory of Virology and Biosafety and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Ticks are crucial vectors for various pathogens associated with human and animal diseases, including viruses. Nevertheless, significant knowledge gaps prevail in our understanding of tick-borne viruses (TBVs). We here examined existing studies on TBVs, uncovering 870 documented virus species across 28 orders, 55 families, and 66 genera.
View Article and Find Full Text PDFmiR-195-5p Inhibits Colon Cancer Progression via KRT23 Regulation.
Pharmaceutics
December 2024
National Institute of Gastroenterology S. De Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, BA, Italy.
Background/objectives: KRT23 was recently discovered as an epithelial-specific intermediate filament protein in the type I keratin family. Many studies have underlined keratin's involvement in several biological processes as well as in the pathogenesis of different diseases. Specifically, KRT23 was reported to affect the structural integrity of epithelial cells and to trigger cellular signaling leading to the onset of cancer.
View Article and Find Full Text PDFInvestigating the Potential Effects of 6PPDQ on Prostate Cancer Through Network Toxicology and Molecular Docking.
Toxics
December 2024
Department of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.
(1) Background: N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPDQ), as a newly discovered environmental toxin, has been found more frequently in our living conditions. The literature reports that damage to the reproductive and cardiovascular system is associated with exposure to 6PPDQ. However, the relationship between 6PPDQ and cancer still requires more investigation.
View Article and Find Full Text PDFEffects of Ketamine vs. Midazolam in Adolescent Treatment Resistant Depression.
Pharmaceuticals (Basel)
December 2024
Clinic of Psychiatry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin, Kollarova 2, 03601 Martin, Slovakia.
Adolescent treatment resistant depression (TRD) is increasing in recent years. While ketamine showed rapid antidepressant effects in adult TRD studies, research on its effectiveness in adolescents is limited. This study examines the effects of intravenous ketamine vs.
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