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Impact of Frailty on Surgical Outcomes of Patients With Cushing Disease Using the Multicenter Registry of Adenomas of the Pituitary and Related Disorders Registry.
Neurosurgery
February 2025
Global Neurosciences Institute, Philadelphia , Pennsylvania , USA.
Background And Objectives: Despite growing interest in how patient frailty affects outcomes (eg, in neuro-oncology), its role after transsphenoidal surgery for Cushing disease (CD) remains unclear. We evaluated the effect of frailty on CD outcomes using the Registry of Adenomas of the Pituitary and Related Disorders (RAPID) data set from a collaboration of US academic pituitary centers.
Methods: Data on consecutive surgically treated patients with CD (2011-2023) were compiled using the 11-factor modified frailty index.
Chromatin enables precise and scalable gene regulation with factors of limited specificity.
Proc Natl Acad Sci U S A
January 2025
Institute of Science and Technology Austria, AT-3400 Klosterneuburg, Austria.
Biophysical constraints limit the specificity with which transcription factors (TFs) can target regulatory DNA. While individual nontarget binding events may be low affinity, the sheer number of such interactions could present a challenge for gene regulation by degrading its precision or possibly leading to an erroneous induction state. Chromatin can prevent nontarget binding by rendering DNA physically inaccessible to TFs, at the cost of energy-consuming remodeling orchestrated by pioneer factors (PFs).
View Article and Find Full Text PDFImpact of vitamin D on hyperoxic acute lung injury in neonatal mice.
BMC Pulm Med
November 2024
Division of Neonatology, Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Background: Prolonged exposure to hyperoxia can lead to hyperoxic acute lung injury (HALI) in preterm neonates. Vitamin D (VitD) stimulates lung maturation and acts as an anti-inflammatory agent. Our objective was to determine if VitD provides a dose-dependent protective effect against HALI by reducing inflammatory cytokine expression and improving alveolarization and lung function in neonatal mice.
View Article and Find Full Text PDFPDGFRα-positive cell-derived TIMP-1 modulates adaptive immune responses to influenza A viral infection.
Am J Physiol Lung Cell Mol Physiol
January 2025
Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, Georgia, United States.
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a physiologic inhibitor of the matrix metalloproteinases (MMPs), but little is known about the role of TIMP-1 in regulating the pathogenesis of influenza A virus (IAV) infection. Here, we performed both in vivo and in vitro experiments to investigate the regulation and function of TIMP-1 during IAV infection. Specifically, plasma levels of TIMP-1 are significantly increased in human subjects and wild-type (WT) mice infected with 2009 H1N1 IAV compared with levels in uninfected controls.
View Article and Find Full Text PDFAntipsychotic prescribing practices and their association with rehospitalization in a forensic psychiatric sample.
Front Psychiatry
October 2024
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Article Synopsis
- There is a lack of research on antipsychotic prescribing practices specifically for patients in forensic psychiatric services, despite extensive literature on their use in general psychiatric settings.
- The study involved 153 forensic psychiatric patients with psychotic illnesses, finding that the majority were middle-aged males, predominantly white, and had serious offenses, with 75.9% prescribed atypical antipsychotics.
- Rehospitalization rates were notable, with 52.9% of patients rehospitalized at least once; clozapine showed lower rehospitalization rates compared to other medications, indicating it may be underused and warrants further investigation.
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