Congenital uterine anomalies have been associated with poor reproductive outcome, which include recurrent miscarriage, abruptio placenta, intra-uterine growth restriction and preterm delivery. Here, we report a case: 36 years old, G3P2, known case of uterine didelphys, with history of preterm birth, who successfully carried her pregnancy till term with weekly intramuscular injection of 250 mg hydroxyprogesterone caproate (®Proluton Depot, Zuellig Pharma).
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Vaginal progesterone for prevention of preterm birth in women with a history of preterm birth regardless of cervical length: an argument against use.
Am J Obstet Gynecol MFM
November 2024
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke Health, Durham, NC, 27710.
Article Synopsis
- - Preterm birth occurs before 37 weeks of gestation and is a leading cause of neonatal and early infant death, making it a critical public health issue.
- - While progesterone supplementation, particularly 17-alpha hydroxyprogesterone caproate, was initially seen as a potential solution for reducing preterm birth risk, its approval was revoked due to limited effectiveness.
- - Recent meta-analyses indicate that vaginal progesterone does not significantly lower the rates of recurring preterm birth in women with previous preterm deliveries, suggesting that its universal use for this purpose may not be justified.
Vaginal administration of 17-alpha hydroxyprogesterone caproate appears to be safe in non-pregnant female rats and rabbits.
Xenobiotica
October 2024
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Intramuscular (250 mg once weekly) or subcutaneous (275 mg once weekly) injections of 17-hydroxyprogesterone caproate (17-OHPC) has been utilised to prevent recurent spontaneous preterm birth in pregnant women with a short cervix or those with a prior preterm birth but its efficacy in these conditions has been questioned. It is unclear whether adequate concentrations of 17-OHPC reach the suspected target organs such as the cervix and uterus following either IM or SC administration.The objective of this study was to determine feasibility and safety of vaginal administration of 17-OHPC in adult female Sprague Dawley rats and female New Zealand rabbits.
View Article and Find Full Text PDFDevelopmental 17-OHPC exposure disrupts behavior regulated by the mesocorticolimbic dopaminergic system in rats.
Pharmacol Biochem Behav
December 2024
Department of Psychology & Center for Neuroscience Research, University at Albany, Albany, NY, USA.
The synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC), is administered to pregnant individuals with the intention of reducing preterm birth. Although there is evidence that 17-OHPC is likely transferred from mother to fetus, there is little information regarding the potential effects of 17-OHPC administration on behavioral and neural development in offspring. Neonatal 17-OHPC exposure disrupts the development of the mesocorticolimbic dopaminergic pathway and associated behaviors in rats.
View Article and Find Full Text PDFConcerns over the emergence of steroid hormones as pollutants in water have grown. Steroid hormone compounds present challenges in the simultaneous detection of total residual hormones owing to their analogous structures and diverse types. In this study, we established a rapid and high-throughput continuous online method based on solid phase extraction (SPE) coupled with ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the simultaneous determination of 61 hormone components, including 48 glucocorticoids, 1 mineralocorticoid, 4 androgens, and 8 progesterones, in water.
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