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Elucidating the molecular association and potential mechanisms between psoriasis and atrial fibrillation through biomarker and immune infiltration analysis.
Arch Dermatol Res
January 2025
Jiangxi Medical College, Nanchang University, Nanchang, China.
Multiple studies have suggested that psoriasis may increase the risk of atrial fibrillation (AF). However, the molecular and immune mechanisms underlying this association remain unclear. This study initially downloaded gene expression profiles for psoriasis and AF from the Gene Expression Omnibus database.
View Article and Find Full Text PDFThe mediating role of the genetically predicted N6, N6, N6-trimethyllysine levels in the association between HLA DR on CD14- CD16+ monocytes and ankylosing spondylitis.
Medicine (Baltimore)
December 2024
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Article Synopsis
- This study investigates the relationship between HLA DR expression on a specific type of immune cell (CD14- CD16+ monocytes) and ankylosing spondylitis (AS), focusing on the role of 1091 blood metabolites as potential mediators.
- Using data from a large genome-wide association study, researchers applied a two-step Mendelian randomization method to analyze the effect of HLA DR levels on the risk of developing AS.
- The findings indicated that higher HLA DR levels were linked to a lower incidence of AS, with N6, N6, N6-trimethyllysine (TML) identified as the key mediator in this relationship, demonstrating its significant impact on AS variance.
Elevated levels of CD56+ T Cells, CD16+ CD56+ T Cells, and CD56dim NK Cells in herpes simplex virus type 1 seropositive healthy individuals.
Saudi Med J
December 2024
From the Department of Clinical Laboratory Sciences (Almehmadi, Allahyani, Aljuaid, Alsuwat), College of Applied Medical Sciences, Taif University, Taif; and from the College of Nursing and Health Sciences (Halawi), Jazan University, Jazan, Kingdom of Saudi Arabia.
Objectives: To investigate the numbers of natural killer (NK) cells, CD56+ T-cells and CD56- T cells, and the levels ofCD16 in healthy individuals seropositive for herpes simplex virus Type 1 (HSV-1). Specifically, it seeks to measure the levels of these cells to learn about the possible immunological significance during HSV-1 seropositive status.
Methods: This study employed a cross-sectional research design to examine the levels of CD56+ T-cells and CD16+ among individuals seropositive for herpes simplex virus type 1 (HSV-1) in Taif city.
Illuminating the enigmatic pathogenesis of Kawasaki disease: Unveiling novel therapeutic avenues by targeting FCGR3B-S100A12 pathway.
Eur J Pharmacol
January 2025
Department of Clinical Laboratory Medicine, Children's Hospital of Nanjing Medical University, China. Electronic address:
Article Synopsis
- Kawasaki disease primarily affects children and can lead to serious heart issues due to drug resistance.
- This study used advanced techniques to find new treatment targets by identifying genes linked to the disease, particularly focusing on FCGR3B and S100A12.
- The researchers propose that the interaction between these two molecules could drive inflammation and contribute to coronary artery damage, highlighting them as potential targets for clinical treatment.
Nutrient transporter pattern in CD56 NK cells: CD16 (FcγRIIIA)-dependent modulation and association with memory NK cell functional profile.
Front Immunol
November 2024
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Background: Human memory NK cells represent a heterogeneous CD56 population that expands and persists in human cytomegalovirus (HCMV)-seropositive healthy individuals. They are characterized by the preferential, not fully overlapping, expression of NKG2C (activating receptor for HLA-E) and CD57 maturation marker, and by the lack of FcεRIγ adaptor chain. Hyperresponsiveness to Fcγ receptor IIIA (CD16) engagement represents the distinctive functional signature of memory NK cells.
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