Background: Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians.
Methods: In 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated loci, individually or in aggregate (as a genetic risk score--GRS), are associated with BMI; b) physical activity and smoking modify the association of these loci with BMI. Analyses were adjusted for age, age(2), sex, MI (yes/no), and population substructure.
Results: Of 95 SNPs studied here, 73 showed directionally consistent effects on BMI as reported in Europeans. Each additional BMI-raising allele of the GRS was associated with 0.04 (SE = 0.01) kg/m(2) higher BMI (P = 4.5 × 10(-14)). We observed nominal evidence of interactions of CLIP1 rs11583200 (P(interaction) = 0.014), CADM2 rs13078960 (P(interaction) = 0.037) and GALNT10 rs7715256 (P(interaction) = 0.048) with physical activity, and PTBP2 rs11165643 (P(interaction) = 0.045), HIP1 rs1167827 (P(interaction) = 0.015), C6orf106 rs205262 (P(interaction) = 0.032) and GRID1 rs7899106 (P(interaction) = 0.043) with smoking on BMI.
Conclusions: Most BMI-associated loci have directionally consistent effects on BMI in Pakistanis and Europeans. There were suggestive interactions of established BMI-related SNPs with smoking or physical activity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683724 | PMC |
| http://dx.doi.org/10.1186/s12881-015-0259-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of shank, rearfoot and forefoot coordination and its variability between runners with different strike patterns.
J Biomech
January 2025
School of Exercise and Health, Shanghai University of Sport, Hengren Rd. 200, Yangpu District, Shanghai 200438, China. Electronic address:
This study aims to compare shank, rearfoot and forefoot coordination and its variability between runners with habitual rearfoot strike (RFS) and non-RFS (NRFS). 58 healthy males participated in this study (32 RFS, 26 NRFS). Coordination patterns and variability were assessed for the shank, rearfoot, and forefoot segments using a modified vector coding technique during running.
View Article and Find Full Text PDFVastus lateralis muscle architecture, quality, and stiffness are determinants of maximal performance in athletes?
J Biomech
January 2025
Exercise Biochemistry Laboratory, Department of Biochemistry and Molecular Biology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.
Understanding intrinsic muscular adaptations more deeply can help clarify their relationships with sports performance. Therefore, the aim of this study was to determine if vastus lateralis muscle architecture, quality and stiffness can explain knee extensor maximal torque and countermovement and squat jump performance of athletes. One hundred and two athletes were evaluated based on the architecture, quality and stiffness of the vastus lateralis at rest.
View Article and Find Full Text PDFAbdominal PP meshes coated with functional core-sheath biodegradable nanofibers with anticoagulant and antibacterial properties.
Biomater Adv
January 2025
Univ. Lille, CNRS, INRAE, Centrale Lille, UMR 8207 - UMET - Unité Matériaux et Transformations, F-59000 Lille, France. Electronic address:
Abdominal hernia repair is a common surgical procedure, involving in most cases the use of textile meshes providing a mechanical barrier to consolidate the damaged surrounding tissues and prevent the resurgence of the hernia. However, in more than half cases postoperative complications such as adhesions and infections occur at the surface of the mesh, leading to chronic pain for the patient and requiring the removal of the implant. One of the most promising strategies to reduce the risk of postoperative adhesions and infections is to add a physical barrier between the mesh and the abdominal walls.
View Article and Find Full Text PDFNovel Fluoroquinolones With Pinane Moiety: Synthesis and Antimicrobial Activity.
Chem Biodivers
January 2025
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Here, we report a synthesis of fluoroquinolones carrying a monoterpene moiety at the C7 position of aromatic structure. The minimal inhibitory concentrations of fluoroquinolone fused with trans-3-hydroxy-cis-myrtanylamine 18 against Staphylococcus aureus (MSSA isolates) were two- to eightfold lower compared to moxifloxacin, although fourfold higher against MRSA isolates. The fluoroquinolone fused with (-)-nopylamine 16 was four- to eightfold less active on MSSA compared to moxifloxacin, while had similar activity on MRSA.
View Article and Find Full Text PDFVitamin D status and its determinants in German elite athletes.
Eur J Appl Physiol
January 2025
Department of Exercise Physiology and Sports Therapy, Institute of Sports Science, Justus Liebig University Giessen, Kugelberg 62, 35394, Giessen, Germany.
Purpose: This study investigated elite German athletes to (1) assess their serum 25(OH)D levels and the prevalence of insufficiency, (2) identify key factors influencing serum 25(OH)D levels, and (3) analyze the association between serum 25(OH)D levels and handgrip strength.
Methods: In this cross-sectional study, a total of 474 athletes (231 female), aged 13-39 years (mean 19.3 years), from ten Olympic disciplines were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!