Scientific Significance of Clinically Insignificant FcγRIIIa-V158F Polymorphism.

Clin Cancer Res

Department of Medicine, Division of Oncology, Stanford University, Stanford, California.

Published: February 2016

Kenkre and colleagues report the absence of correlation between FcγRIIIa-V158F polymorphism and rituximab response in follicular lymphoma patients, a result which is in contrast with prior studies. This discrepancy recalls that many other factors (from the host and from the tumor) may influence the efficacy of rituximab in vivo.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2777DOI Listing

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