AI Article Synopsis
- Researchers created mixed CO/NO-releasing molecules by attaching a rhenium complex to modified vitamin B12 molecules.
- These new compounds were thoroughly analyzed using techniques like X-ray crystallography.
- When tested, the B12 derivatives showed the ability to release low doses of nitric oxide in solution and provided some protective effects in cell models, but did not enhance the effects more than their individual components.
Article Abstract
Mixed CO/NO-releasing molecules were prepared by conjugation of the 17-electron rhenium dicarbonyl cis-[Re(CO)2Br4](2-) complex to N-nitrosamine modified cyanocobalamin (B12) bio-vectors. The species were fully characterized by standard analytical techniques, including X-ray crystallography for cyanocobalamin-5'-O-pyrazine and () and its N-pyrazine nitrosylated derivative (). The N-nitrosamine B12 derivatives are able to liberate low NO doses in buffer solutions and appear to be "activated" towards NO release if in contact with cultured cells. Coordination of the cis-[Re(CO)2Br4](2-) complex on the axial cyanide of B12 allows for the combined loss of CO and NO from the conjugates. The mixed CO/NO-releasing molecules show cytoprotection in an ischemia-reperfusion model but no significant enhanced synergistic effects over the relative NORMs and CORMs building constituents.
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| http://dx.doi.org/10.1039/c5dt03402g | DOI Listing |
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N-Nitrosamine-{cis-Re[CO]2}(2+) cobalamin conjugates as mixed CO/NO-releasing molecules.
Dalton Trans
January 2016
Department of Chemistry, University of Fribourg, Chemin du Musée 9, CH-1700 Fribourg, Switzerland.
Article Synopsis
- Researchers created mixed CO/NO-releasing molecules by attaching a rhenium complex to modified vitamin B12 molecules.
- These new compounds were thoroughly analyzed using techniques like X-ray crystallography.
- When tested, the B12 derivatives showed the ability to release low doses of nitric oxide in solution and provided some protective effects in cell models, but did not enhance the effects more than their individual components.
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