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Dual-mode ultrasensitive detection of acute leukemia gene Pax-5a based on smart DNA programmed dendrimer.
Biosens Bioelectron
December 2024
State Key Laboratory for Chemo/Biosensing and Chemometrics, Hunan University, Changsha, 410082, PR China.
Accurate and sensitive detection of Pax-5a gene is the basis of early diagnosis and prediction of acute leukemia. This research aims to develop a universal dual-mode sensing method enables ultrasensitive gene detection based on smart control of DNA amplification by nucleic acid beacons e to form programmed dendrimer. The Pax-5a target gene triggers the opening of smart gate hairpin probe (Hp), exposing the stem sequence as the primer to bind with padlock probe for rolling circle amplification (RCA).
View Article and Find Full Text PDFRobust ferromagnetism in wafer-scale FeGaTe above room-temperature.
Nat Commun
December 2024
School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, China.
The discovery of ferromagnetism in van der Waals (vdW) materials has enriched the understanding of two-dimensional (2D) magnetic orders and opened new avenues for fundamental physics research and next generation spintronics. However, achieving ferromagnetic order at room temperature, along with strong perpendicular magnetic anisotropy, remains a significant challenge. In this work, we report wafer-scale growth of vdW ferromagnet FeGaTe using molecular beam epitaxy.
View Article and Find Full Text PDFInterplay between A-site and oxygen-vacancy ordering, and mixed electron/oxide-ion conductivity in = 1 Ruddlesden-Popper perovskite SrNdZnO.
Chem Sci
December 2024
College of Chemistry and Chemical Engineering, Chongqing University Chongqing 401331 China
Oxygen vacancies in Ruddlesden-Popper (RP) perovskites (PV) [AO][ABO] play a pivotal role in engineering functional properties and thus understanding the relationship between oxygen-vacancy distribution and physical properties can open up new strategies for fine manipulation of structure-driven functionalities. However, the structural origin of preferential distribution for oxygen vacancies in RP structures is not well understood, notably in the single-layer ( = 1) RP-structure. Herein, the = 1 RP phase SrNdZnO was rationally designed and structurally characterized by combining three-dimensional (3D) electron diffraction and neutron powder diffraction.
View Article and Find Full Text PDFDantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.
Structure
December 2024
Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address:
Mutations in the skeletal isoform of the ryanodine receptor 1 (RyR1) pose grave risks during anesthesia or treatment with succinylcholine muscle relaxants. These can trigger a potentially lethal malignant hyperthermia (MH) episode via intracellular calcium increase mainly from RyR1 channel leakage. Dantrolene is the only known treatment option to prevent death.
View Article and Find Full Text PDFDeterministic quantum state and gate teleportation between distant superconducting chips.
Sci Bull (Beijing)
December 2024
Shenzhen Institute for Quantum Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China; International Quantum Academy, Shenzhen 518048, China; Guangdong Provincial Key Laboratory of Quantum Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China; Department of Physics, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:
Quantum teleportation is of both fundamental interest and great practical importance in quantum information science. To date, quantum teleportation has been implemented in various physical systems, among which superconducting qubits are of particular practical significance as they emerge as a leading system to realize large-scale quantum computation. Nevertheless, scaling up the number of superconducting qubits on a single chip becomes increasing challenging because of some emergent technical difficulties.
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